Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biofactors. 2020 Sep;46(5):698-715. doi: 10.1002/biof.1669. Epub 2020 Aug 14.
Exosomes, as small vesicles, are released by tumor cells and tumor microenvironment (cells and function as key intercellular mediators and effects on different processes including tumorigenesis, angiogenesis, drug resistance, and evasion from immune system. These functions are due to exosomes' biomolecules which make them as efficient markers in early diagnosis of the disease. Also, exosomes have been recently applied in vaccination. The potential role of exosomes in immune response toward leukemic cells makes them efficient immunotherapeutic agents treating leukemia. Furthermore, variations in exosomes contents make them beneficial to be used in treating different diseases. This review introduces the role of exosomes in the development of hematological malignancies and evaluates their functional role in the treatment of these malignancies.
外泌体作为小囊泡，由肿瘤细胞和肿瘤微环境（细胞和功能）释放，充当关键的细胞间介质，并对包括肿瘤发生、血管生成、耐药性和逃避免疫系统在内的不同过程产生影响。这些功能归因于外泌体的生物分子，使其成为疾病早期诊断的有效标志物。此外，外泌体最近已被应用于疫苗接种。外泌体在免疫反应对白血病细胞中的作用使它们成为治疗白血病的有效免疫治疗剂。此外，外泌体内容物的变化使它们有益于用于治疗不同的疾病。本综述介绍了外泌体在血液系统恶性肿瘤发展中的作用，并评估了它们在治疗这些恶性肿瘤中的功能作用。
