青少年人群中心血管风险与总白细胞计数、白细胞亚群及其指数的关系。

Total leukocyte count, leukocyte subsets and their indexes in relation to cardiovascular risk in adolescent population.

机构信息

Center for Laboratory Diagnostics, Primary Health Care Center, University of Montenegro-Faculty of Medicine, Podgorica, Montenegro.

出版信息

Eur Rev Med Pharmacol Sci. 2021 Apr;25(7):3038-3044. doi: 10.26355/eurrev_202104_25557.

DOI:10.26355/eurrev_202104_25557

PMID:33877667

Abstract

OBJECTIVE

No studies investigated total leukocytes, their subpopulations and novel indexes based on different ratios of leukocyte subsets concerning cardiovascular risk (CV) risk in late adolescents. Therefore, the aim of the present study was to explore such potential relationships.

PATIENTS AND METHODS

A total of 156 adolescents were included. CV risk score was calculated by summarizing each risk factor (i.e., female sex, low high density lipoprotein cholesterol (HDL-c), high non-HDL-c, smoking, blood pressure, and fasting glycemia). Adolescents were divided into a low CV risk score (i.e., -2≤ CV risk score ≤1) and moderate/higher CV risk score (i.e., CV risk score ≥ 2). White blood cell count (WBC) and its subsets were analyzed on an automatic device. The indexes were calculated.

RESULTS

Total and differential WBC counts except basophil count were higher in moderate/higher CV risk participants. Multivariate binary regression analysis showed that total WBC count independently increased CV risk score by 1.623 times (p=0.001). Neutrophil and eosinophil counts (p=0.027 and p=0.010, respectively) were independently able to increase CV risk score by 1.486 and 1.556 times, respectively. On the contrary, indexes were not independently correlated with CV risk.

CONCLUSIONS

WBC, neutrophil, and eosinophil count are the independent predictors of increased CV risk in adolescents. The associations may indicate the different pathways that lead to CV disease in adulthood.

摘要

目的

目前尚无研究调查白细胞总数及其亚群以及基于白细胞亚群不同比例的新型指标与青少年晚期心血管风险（CV）之间的关系。因此，本研究旨在探讨这种潜在的关系。

患者和方法

共纳入 156 名青少年。通过汇总每个危险因素（即女性、低高密度脂蛋白胆固醇（HDL-c）、高非高密度脂蛋白胆固醇、吸烟、血压和空腹血糖）来计算 CV 风险评分。将青少年分为低 CV 风险评分（即 -2≤CV 风险评分≤1）和中/高 CV 风险评分（即 CV 风险评分≥2）。在自动设备上分析白细胞计数（WBC）及其亚群。计算了指标。

结果

中/高 CV 风险参与者的总白细胞计数和差异白细胞计数（除嗜碱性粒细胞计数外）较高。多元二项回归分析显示，总白细胞计数使 CV 风险评分独立增加 1.623 倍（p=0.001）。中性粒细胞和嗜酸性粒细胞计数（分别为 p=0.027 和 p=0.010）分别能够使 CV 风险评分独立增加 1.486 倍和 1.556 倍。相反，这些指标与 CV 风险无独立相关性。