Volkos Panagiotis, Linardakis Manolis, Symvoulakis Emmanouil K
Clinic of Social and Family Medicine, School of Medicine, University of Crete, 71003 Heraklion, Greece.
J Clin Med. 2025 Jun 14;14(12):4236. doi: 10.3390/jcm14124236.
C-reactive protein (CRP) has been acknowledged to be associated with depression, loneliness, and stress, as well as physical health conditions. The aim of this study was to explore possible associations between CRP semi-quantitative readings and demographic, social, behavioral, and biomedical indices. : Group sampling took place between May and July 2023, and from the 120 non-obese participants initially registered in the study, a random selection of n = 80 was performed for blood sampling in order to measure plasma semi-quantitative CRP (higher levels or ≥10 mg/L and lower or <10) and plasma dopamine. Blood sample collection took place between December 2023 and June 2024. Personal sociability, subjective loneliness, and perceived stress were assessed using relevant scales. Hierarchical multiple logistic regression analysis was also performed. : A unit increase in Body Mass Index (BMI) was related to higher odds for greater semi-quantitative CRP levels (OR = 1.26, = 0.033) while for each unit increase in the Personal Sociability and Connections scale (PeSCs), the odds for higher CRP levels decreased (OR = 0.91, = 0.025). Lower age (OR = 0.90, = 0.009) and higher number of prescribed medications per day (OR = 4.21, = 0.049) also showed significant associations with high semi-quantitative CRP levels. Plasma dopamine and other scale scores used did not show significant associations ( > 0.05), despite some interesting descriptive trends. : The presented results suggest that age, BMI, number of prescribed medications per day, sociability, and CRP readings are constellated in everyday consultations.
C反应蛋白（CRP）已被认为与抑郁、孤独、压力以及身体健康状况有关。本研究的目的是探讨CRP半定量读数与人口统计学、社会、行为和生物医学指标之间可能存在的关联。：2023年5月至7月进行分组抽样，从最初登记参加该研究的120名非肥胖参与者中随机抽取n = 80名进行血液采样，以测量血浆半定量CRP（较高水平或≥10mg/L以及较低水平或<10）和血浆多巴胺。血液样本采集于2023年12月至2024年6月进行。使用相关量表评估个人社交能力、主观孤独感和感知压力。还进行了分层多元逻辑回归分析。：体重指数（BMI）每增加一个单位，半定量CRP水平升高的几率就更高（OR = 1.26， = 0.033），而个人社交能力与人际关系量表（PeSCs）每增加一个单位，CRP水平升高的几率就降低（OR = 0.91， = 0.025）。较低的年龄（OR = 0.90， = 0.009）和每天较高的处方药数量（OR = 4.21， = 0.049）也与高半定量CRP水平显示出显著关联。尽管有一些有趣的描述性趋势，但所使用的血浆多巴胺和其他量表分数未显示出显著关联（>0.05）。：呈现的结果表明，在日常会诊中，年龄、BMI、每天的处方药数量、社交能力和CRP读数相互关联。
