Department of Anaesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA.
Eur Rev Med Pharmacol Sci. 2021 Apr;25(7):3136-3144. doi: 10.26355/eurrev_202104_25569.
Disruption of intracellular Ca2+ homeostasis via excessive and pathological Ca2+ release from the endoplasmic reticulum (ER) and/or sarcoplasmic reticulum (SR) through ryanodine receptor (RyRs) Ca2+ channels play a critical role in the pathology of systemic inflammatory response syndrome (SIRS) and associated multiple organ dysfunction syndrome (MODS) in sepsis or septic shock. Dantrolene, a potent inhibitor of RyRs, is expected to ameliorate SIRS and MODS and decrease mortality in sepsis or septic shock patients. This review summarized the potential mechanisms of therapeutic effects of dantrolene in sepsis or septic shock at molecular, cell, and organ levels and provided suggestions and strategies for future clinical studies.
细胞内钙离子稳态的破坏，通过内质网（ER）和/或肌浆网（SR）中过度和病理性的钙离子释放，通过兰尼碱受体（RyRs）钙离子通道，在全身炎症反应综合征（SIRS）和相关的多器官功能障碍综合征（MODS）的病理生理学中发挥关键作用，在败血症或感染性休克中。丹曲林钠，一种 RyRs 的有效抑制剂，有望改善败血症或感染性休克中的 SIRS 和 MODS，并降低败血症或感染性休克患者的死亡率。这篇综述总结了丹曲林钠在败血症或感染性休克中在分子、细胞和器官水平上的治疗效果的潜在机制，并为未来的临床研究提供了建议和策略。
