Pan Qingrong, Gao Shuxin, Gao Xia, Yang Ning, Yao Zhi, Hu Yanjin, Miao Li, Chen Zhe, Wang Guang
Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.
Department of General Practice, Cangzhou Central Hospital, Cangzhou, Hebei Province, China.
Endocr Connect. 2021 May 13;10(5):502-510. doi: 10.1530/EC-21-0069.
It has been found that both serum homocysteine (Hcy) and serum creatinine levels were increased in hypothyroidism patients. The aim of this study was to investigate the correlation between serum Hcy and kidney function in patients with subclinical hypothyroidism or hypothyroidism.
A total of 448 subjects were enrolled and divided into three groups: hypothyroidism (n = 129), subclinical hypothyroidism (n = 141), and control group (n = 168). Anthropometric information, metabolic parameters, serum Hcy and creatinine levels, and estimated glomerular filtration rate (eGFR) were analyzed.
Compared with healthy subjects, patients with subclinical hypothyroidism or hypothyroidism had significantly higher serum Hcy and creatinine levels and lower eGFR level (all P < 0.001). Serum Hcy was negatively correlated with eGFR in subclinical hypothyroidism patients (r = -0.220, P = 0.009), and in hypothyroidism patients (r = -0.422, P < 0.001). After adjusting for age, sex and BMI, eGFR was still significantly correlated with serum Hcy in subclinical hypothyroidism or hypothyroidism patients (both P < 0.05). Levothyroxine treatment resulted in significantly decreased Hcy and increased eGFR in hypothyroidism patients (both P < 0.001). The decrease in Hcy was correlated with the increased eGFR after treatment (P = 0.001).
Serum Hcy was negatively correlated with eGFR in subclinical hypothyroidism or hypothyroidism patients. After levothyroxine treatment, a correlation was found between the decrease in serum Hcy and the increase in eGFR in hypothyroidism patients.
已发现甲状腺功能减退患者的血清同型半胱氨酸（Hcy）和血清肌酐水平均升高。本研究的目的是探讨亚临床甲状腺功能减退或甲状腺功能减退患者血清Hcy与肾功能之间的相关性。
共纳入448名受试者，分为三组：甲状腺功能减退组（n = 129）、亚临床甲状腺功能减退组（n = 141）和对照组（n = 168）。分析人体测量信息、代谢参数、血清Hcy和肌酐水平以及估计肾小球滤过率（eGFR）。
与健康受试者相比，亚临床甲状腺功能减退或甲状腺功能减退患者的血清Hcy和肌酐水平显著更高，而eGFR水平更低（所有P < 0.001）。亚临床甲状腺功能减退患者中血清Hcy与eGFR呈负相关（r = -0.220，P = 0.009），在甲状腺功能减退患者中也是如此（r = -0.422，P < 0.001）。在调整年龄、性别和BMI后，亚临床甲状腺功能减退或甲状腺功能减退患者的eGFR仍与血清Hcy显著相关（两者P < 0.05）。左甲状腺素治疗使甲状腺功能减退患者的Hcy显著降低，eGFR升高（两者P < 0.001）。治疗后Hcy的降低与eGFR的升高相关（P = 0.001）。
亚临床甲状腺功能减退或甲状腺功能减退患者的血清Hcy与eGFR呈负相关。左甲状腺素治疗后，甲状腺功能减退患者血清Hcy的降低与eGFR的升高之间存在相关性。
