Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Breast Diseases Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.
Arch Iran Med. 2021 Mar 1;24(3):209-217. doi: 10.34172/aim.2021.32.
The study aimed at evaluating steroid biomarker genes (α, , β) and determining the expression level of estrogen-regulated genes ( and ) and growth factors receptors (HER2 and IGFR1) in cancer tissue samples obtained from Iranian patients with breast cancer. Moreover, relationships with clinicopathologic aspects of tumor and response to treatment were studied.
The current study was conducted on 246 breast tissue samples. The expression levels of these genes and their relationships with clinicopathologic aspects and treatment response were evaluated.
Based on immunohistochemistry (IHC) results, 12% of the ER negative patients expressed ERα. Comparing the effects of ERα and coexpression of and on the survival of the patients demonstrated remarkably poorer survival in ERα positive, SCUBE2, and BCL2 negative groups in comparison with other patients, which was statistically significant in the log-rank analysis ( = 0.01). Evaluation of the effects of coexpression of and on patients' survival demonstrated a worse survival rate in patients with positive expression of both receptors, which was insignificant.
Many studies suggest that PGR alone is not enough for the functional evaluation of ERα. Evaluation of the progesterone receptor expression as well as other genes such as , , and , seems necessary to evaluate functionality.
本研究旨在评估甾体生物标志物基因（α、β），并测定伊朗乳腺癌患者癌组织样本中雌激素调节基因（和）和生长因子受体（HER2 和 IGFR1）的表达水平。此外，还研究了它们与肿瘤临床病理特征和治疗反应的关系。
本研究共纳入 246 例乳腺癌组织样本。评估了这些基因的表达水平及其与临床病理特征和治疗反应的关系。
根据免疫组化（IHC）结果，12%的 ER 阴性患者表达 ERα。比较 ERα和共表达和对患者生存的影响表明，与其他患者相比，ERα 阳性、SCUBE2 阴性和 BCL2 阴性组的患者生存明显更差，对数秩分析有统计学意义（=0.01）。评估共表达和对患者生存的影响表明，两个受体均阳性的患者生存率更差，但无统计学意义。
许多研究表明，PGR 单独不足以评估 ERα 的功能。评估孕激素受体表达以及其他基因，如、、和，对于评估其功能似乎是必要的。
