Keshavan M S, Sanders R D, Pettegrew J W, Dombrowsky S M, Panchalingam K S
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213.
Schizophr Res. 1993 Oct;10(3):241-6. doi: 10.1016/0920-9964(93)90058-q.
The relation between frontal lobe membrane phospholipid metabolism as measured by 31Phosphorus magnetic resonance spectroscopy (31P MRS) and cerebral morphology as measured on magnetic resonance images (MRI) was examined in nine first episode neuroleptic naive schizophrenic patients. Total corpus callosal area was significantly correlated with phosphodiester concentration. When examined separately, this relation was confined to the rostral quartile (genu) of the corpus callosum. The pathophysiological significance of this finding is discussed in relation to neurodevelopmental hypotheses of schizophrenia.
通过31磷磁共振波谱（31P MRS）测量的额叶膜磷脂代谢与通过磁共振成像（MRI）测量的脑形态之间的关系，在9名首次发作、未服用过抗精神病药物的精神分裂症患者中进行了研究。胼胝体总面积与磷酸二酯浓度显著相关。当分别检查时，这种关系仅限于胼胝体的前部四分之一（膝部）。结合精神分裂症的神经发育假说讨论了这一发现的病理生理学意义。
