伊维菌素群体药物治疗对尼日利亚奥贡州盘尾丝虫病蚊媒种群的影响。

Impacts of ivermectin mass drug administration for onchocerciasis on mosquito populations of Ogun state, Nigeria.

机构信息

Department of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Ogun, Nigeria.

Department of Animal and Environmental Biology, Federal University Oye Ekiti, Ekiti, Nigeria.

出版信息

Parasit Vectors. 2021 Apr 20;14(1):212. doi: 10.1186/s13071-021-04716-3.

DOI:10.1186/s13071-021-04716-3

PMID:33879232

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8056593/

Abstract

BACKGROUND

The impact of single-dose mass drug administration (MDA) of ivermectin for onchocerciasis on mosquito populations was investigated in Ogun State, Nigeria.

METHODS

Indoor and outdoor collection of mosquitoes was carried out in two intervention (IC) and two control communities (CC) at three different periods: pre-MDA (baseline), 2-3 days after MDA and 13-14 days after MDA. The density and parity rate of female Anopheles and Culex mosquitoes were determined and compared. Environmental and climatic data of study locations were obtained to perform generalized linear model analysis.

RESULTS

A total of 1399 female mosquitoes were collected, including 1227 Anopheles and 172 Culex mosquitoes. There was a similar magnitude of reduction in the indoor density of Anopheles by 29% in the IC and CC 2-3 days post-MDA but the reduction in indoor parity rate was significantly higher (p = 0.021) in the IC, reducing by more than 50%. In the IC, observation of a significant reduction at 2-3 days post-MDA was consistent for both the indoor density (1.43 to 1.02) and indoor parity rate (95.35% to 44.26%) of Anopheles mosquitoes. The indoor parity rate of Anopheles remained significantly reduced (75.86%) 13-14 post-MDA. On the other hand, the indoor density of Culex increased from 0.07 to 0.10 at 2-3 days post-MDA while the indoor parity rate of Culex did not change. The outdoor density of Anopheles in the IC increased (p = 0.394) from 0.58 to 0.90 at 2-3 days post-MDA; a similar observation was consistent for the outdoor density (2.83 to 3.90) and outdoor parity rate (70.59% to 97.44%) of Culex, while the outdoor parity rate of Anopheles reduced from 85.71 to 66.67% at 2-3 days post-MDA. A generalized linear model showed that ivermectin MDA significantly caused a reduction in both the indoor density (p < 0.001) and indoor parity rate (p = 0.003) of Anopheles in the IC.

CONCLUSION

Ivermectin MDA resulted in the reduction of both the survival and density of Anopheles mosquitoes. This has strong implications for malaria transmission, which depends strongly on vector survival.

摘要

背景

在尼日利亚奥贡州，研究了单次大规模药物驱虫（MDA）伊维菌素对盘尾丝虫病的蚊群的影响。

方法

在两个干预区（IC）和两个对照区（CC）的三个不同时期进行室内和室外蚊子收集：MDA 前（基线）、MDA 后 2-3 天和 MDA 后 13-14 天。确定并比较了雌性疟蚊和库蚊的密度和生殖率。获得研究地点的环境和气候数据，以进行广义线性模型分析。

结果

共收集了 1399 只雌性蚊子，包括 1227 只疟蚊和 172 只库蚊。IC 和 CC 中，室内密度的降低幅度相似，均为 29%，但室内生殖率的降低幅度更高（p=0.021），超过 50%。在 IC 中，在 MDA 后 2-3 天观察到的显著降低情况一致，包括室内密度（从 1.43 降至 1.02）和室内生殖率（从 95.35%降至 44.26%）的降低情况。MDA 后 13-14 天，室内生殖率的降低仍然非常显著（75.86%）。另一方面，Culex 的室内密度从 MDA 后 2-3 天的 0.07 增加到 0.10，而 Culex 的室内生殖率没有变化。MDA 后 2-3 天，IC 中室内疟蚊密度增加（p=0.394），从 0.58 增加到 0.90；类似的观察结果与库蚊的室外密度（从 2.83 增加到 3.90）和室外生殖率（从 70.59%增加到 97.44%）一致，而 MDA 后 2-3 天，室内疟蚊的室外生殖率从 85.71%降低到 66.67%。广义线性模型表明，伊维菌素 MDA 显著降低了 IC 中室内密度（p<0.001）和室内生殖率（p=0.003）。