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中国西部儿童呼吸道病毒流行的特征和预测。

Characteristics and forecasting of respiratory viral epidemics among children in west China.

机构信息

Department of Laboratory Medicine, West China Second University Hospital.

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education.

出版信息

Medicine (Baltimore). 2021 Apr 23;100(16):e25498. doi: 10.1097/MD.0000000000025498.

Abstract

We aimed to assess the respiratory virus characteristics and forecasts among young children with acute respiratory tract infection (ARTI) in west China.This retrospective study investigated the epidemic characteristics of respiratory viruses among 11,813 paediatric ARTI patient samples (mean age, 2.25 years) between March 2018 and March 2020.The ratio of boys to girls was 1.36. The 2 predominant viruses were influenza (Flu) A and respiratory syncytial virus (RSV) in both years, with Flu A accounting for 47.3% and 47.5% in the first and second years and RSV accounting for 32.7% and 24.7% of the positive samples in the first and second years, respectively. The Flu B positive rates were 10.9% and 13.1%, and those of the other 4 viruses were <7%. The most common virus was RSV in children below 5 years and Flu A in those between 5 and 10 years. Flu A and RSV demonstrated pronounced seasonality, and their infection rates increased from October. During the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, isolation measures led to a decline in the number of ARTI cases.This study provides surveillance data of the respiratory viruses in west China. It could guide medical staff in implementing necessary prevention and management strategies before future viral outbreaks.

摘要

本研究旨在评估中国西部急性呼吸道感染(ARTI)患儿的呼吸道病毒特征和预测。该回顾性研究调查了 2018 年 3 月至 2020 年 3 月期间 11813 例儿科 ARTI 患者样本(平均年龄 2.25 岁)的呼吸道病毒流行特征。男女性别比为 1.36。两年中最主要的两种病毒均为流感(Flu)A 和呼吸道合胞病毒(RSV),Flu A 在第 1 年和第 2 年的阳性率分别为 47.3%和 47.5%,RSV 在第 1 年和第 2 年的阳性率分别为 32.7%和 24.7%。Flu B 的阳性率分别为 10.9%和 13.1%,其他 4 种病毒的阳性率均<7%。5 岁以下儿童最常见的病毒是 RSV,5-10 岁儿童最常见的病毒是 Flu A。Flu A 和 RSV 具有明显的季节性,其感染率从 10 月开始上升。在严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)大流行期间,隔离措施导致 ARTI 病例数量下降。本研究提供了中国西部呼吸道病毒的监测数据。它可以指导医务人员在未来病毒爆发前实施必要的预防和管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f98/8078258/13c61c0e2ec0/medi-100-e25498-g001.jpg

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