Hashimoto Hirotaka, Arai Kiyomi, Takahashi Jiro, Chikuda Makoto
Tsukuba Hashimoto Optical Clinic, 530 Furuku, Tsukuba-shi, Ibaraki 305-0021, Japan.
Department of Ophthalmology, Saitama Medical Center, Dokkyo Medical University, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-8555, Japan.
J Clin Biochem Nutr. 2021 Mar;68(2):169-172. doi: 10.3164/jcbn.20-87. Epub 2020 Sep 17.
We previously evaluated the antioxidative effects of astaxanthin intake in the aqueous humor by measuring reactive oxygen species-related parameters, including O scavenging activity, HO level, and total hydroperoxides level. In this study, we analyzed the antioxidative effects of astaxanthin in relation to age in 16 males and 19 females (average age 71.3 and 70.6, respectively) who underwent bilateral cataract surgery on one side before and the other side after astaxanthin intake (6 mg/day for 2 weeks). None of the parameters correlated with age before astaxanthin intake, but only total hydroperoxides level was significantly correlated after the astaxanthin intake ( = 0.4, <0.05). Total hydroperoxides levels were similar in younger and older patients (<70 vs ≥70 years) before astaxanthin, but decreased significantly more in younger patients (-0.21 ± 0.18 vs -0.05 ± 0.31, <0.05) after the intake, resulting in significantly different levels (<0.05). The previously observed decrease in mean total hydroperoxides levels following astaxanthin intake was therefore considered likely to be attributable to a greater response in younger subjects. Given that total hydroperoxides levels reflect general antioxidative status, astaxanthin intake may exert a greater antioxidative effect in younger patients. Further comparative studies involving younger subjects and different astaxanthin doses are needed.
我们之前通过测量与活性氧相关的参数，包括超氧阴离子清除活性、羟基自由基水平和总氢过氧化物水平，评估了眼房水中摄入虾青素的抗氧化作用。在本研究中，我们分析了虾青素对年龄的抗氧化作用，研究对象为16名男性和19名女性（平均年龄分别为71.3岁和70.6岁），他们一侧眼睛在摄入虾青素（6毫克/天，持续2周）前进行了双侧白内障手术，另一侧眼睛在摄入虾青素后进行手术。在摄入虾青素之前，没有任何参数与年龄相关，但摄入虾青素后只有总氢过氧化物水平显著相关（r = 0.4，P < 0.05）。在摄入虾青素之前，年轻患者（<70岁）和老年患者（≥70岁）的总氢过氧化物水平相似，但摄入后年轻患者的总氢过氧化物水平显著下降更多（-0.21±0.18对-0.05±0.31，P < 0.05），导致两者水平有显著差异（P < 0.05）。因此，之前观察到的摄入虾青素后平均总氢过氧化物水平的下降可能归因于年轻受试者的反应更大。鉴于总氢过氧化物水平反映了总体抗氧化状态，摄入虾青素可能在年轻患者中发挥更大的抗氧化作用。需要进一步开展涉及年轻受试者和不同虾青素剂量的比较研究。
