Tsukuba Hashimoto Optical Clinic, 530 Furuku, Tsukuba, Ibaraki 305-0021, Japan ; Department of Ophthalmology, Koshigaya Hospital, Dokkyo University School of Medicine, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-8555, Japan.
J Clin Biochem Nutr. 2013 Jul;53(1):1-7. doi: 10.3164/jcbn.13-6. Epub 2013 May 18.
We evaluated the antioxidative effects of astaxanthin through the changes in superoxide scavenging activity, levels of hydrogen peroxide and total hydroperoxides in human aqueous humor. The study subjects were 35 patients who underwent bilateral cataract surgery on one side before and the other side after intake of astaxanthin (6 mg/day for 2 weeks). Their aqueous humor was taken during the surgery and subjected to measurements of the three parameters. After astaxanthin intake, the superoxide scavenging activity was significantly (p<0.05) elevated, while the level of total hydroperoxides was significantly (p<0.05) lowered. There was a significant negative correlation between the superoxide scavenging activity and the level of total hydroperoxides (r = -0.485, p<0.01), but no correlations between the hydrogen peroxide level and the other two parameters. Astaxanthin intake clearly enhanced the superoxide scavenging activity and suppressed the total hydroperoxides production in human aqueous humor, indicating the possibility that astaxanthin has suppressive effects on various oxidative stress-related diseases.
我们通过观察超氧阴离子清除活性、人眼房水中过氧化氢和总过氧化物水平的变化来评估虾青素的抗氧化作用。研究对象为 35 名患者，他们在一侧双眼接受白内障手术后，另一侧在摄入虾青素（每天 6 毫克，持续 2 周）后接受手术。在手术过程中采集他们的房水，并对这三个参数进行测量。虾青素摄入后，超氧阴离子清除活性显著升高（p<0.05），而过氧化物总水平显著降低（p<0.05）。超氧阴离子清除活性与总过氧化物水平之间存在显著的负相关关系（r=-0.485，p<0.01），但过氧化氢水平与其他两个参数之间没有相关性。虾青素摄入明显增强了人眼房水中的超氧阴离子清除活性，并抑制了总过氧化物的产生，表明虾青素可能对各种与氧化应激相关的疾病具有抑制作用。
