Hashimoto Hirotaka, Arai Kiyomi, Takahashi Jiro, Chikuda Makoto
Tsukuba Hashimoto Optical Clinic, 530 Furuku, Tsukuba-shi, Ibaraki 305-0021, Japan.
Department of Ophthalmology, Saitama Medical Center, Dokkyo Medical University, 2-1-50 Minamikoshigaya, Koshigaya-shi, Saitama 343-8555, Japan.
J Clin Biochem Nutr. 2019 Jul;65(1):47-51. doi: 10.3164/jcbn.18-110. Epub 2019 Apr 18.
In our previous report, we showed the effect of astaxanthin intake on VEGF level in the aqueous humor and the relationship between VEGF level and reactive oxygen species-related parameters and other relevant factors. VEGF level is associated with total hydroperoxide level, and a multivariate analysis identified sex as a secondary factor affecting these relationships. Here, we analyzed the effects of astaxanthin on the relationship between VEGF level and reactive oxygen species-related parameters by sex. Patients (16 males and 19 females, aged 71.3 and 70.6, respectively) underwent bilateral cataract surgery on one side before and the other side after astaxanthin treatment (6 mg/day for 2 weeks). Levels of VEGF, hydrogen peroxide, and total hydroperoxide, and O scavenging activity, were measured in the aqueous humor. In females only, VEGF level was negatively correlated with O scavenging activity before the astaxanthin intake ( = -0.6, <0.01) and positively correlated with total hydroperoxide level before and after the astaxanthin intake ( = 0.7 and 0.8, respectively, <0.01). In conclusion, astaxanthin appears to affect O scavenging activity in the aqueous humor in females, and is likely to be involved in the control of VEGF levels in the anterior eye.
在我们之前的报告中，我们展示了摄入虾青素对房水中血管内皮生长因子（VEGF）水平的影响，以及VEGF水平与活性氧相关参数及其他相关因素之间的关系。VEGF水平与总过氧化氢水平相关，多变量分析确定性别是影响这些关系的次要因素。在此，我们按性别分析了虾青素对VEGF水平与活性氧相关参数之间关系的影响。患者（16名男性和19名女性，年龄分别为71.3岁和70.6岁）在虾青素治疗前（6毫克/天，持续2周）一侧接受双侧白内障手术，另一侧在治疗后接受手术。测量房水中VEGF、过氧化氢、总过氧化氢水平以及氧清除活性。仅在女性中，摄入虾青素前VEGF水平与氧清除活性呈负相关（r = -0.6，P<0.01），摄入虾青素前后VEGF水平与总过氧化氢水平呈正相关（分别为r = 0.7和0.8，P<0.01）。总之，虾青素似乎会影响女性房水中的氧清除活性，并且可能参与眼前部VEGF水平的调控。
