Ahmed Fahad W, Kirresh Omar Z, Robinson Alyss V, Majeed M S, Rouse Dominique, Banatwalla Rumaisa, Parthasarathy Sathish, Sargent Catherine, Castledine Clare, Chakera Ali J
Diabetes and Endocrinology, Brighton and Sussex University Hospitals NHS Trust, Brighton, GBR.
Diabetes and Endocrinology, Western Sussex Hospital NHS Foundation Trust, Worthing, GBR.
Cureus. 2021 Mar 15;13(3):e13902. doi: 10.7759/cureus.13902.
Aim The aim of the study was to compare the clinical characteristics and outcomes (mortality, intensive care admission, mechanical ventilation, and length of stay, LoS) of patients with and without diabetes with confirmed COVID-19. Methods This retrospective study evaluated clinical and laboratory variables in adult inpatients from Brighton and Sussex University Hospitals NHS Trust with laboratory-confirmed COVID-19 between March 10, 2020, and June 30, 2020. Univariate and multivariate analyses were performed to compare the outcomes of patients with and without diabetes. Results Over 457 patients were included in this study (140 with diabetes and 317 without diabetes), of which 143 (31.9%) died. The median age was 80 years and were predominantly males (59.1%). Baseline characteristics at the time of COVID-19 diagnosis demonstrated that the patients with diabetes were younger than those without diabetes (p=0.008). Mortality increased with age. There was no difference in adverse outcomes in those with and without diabetes. However, subgroup analysis of patients aged ≤60 years demonstrated a significantly increased mortality in those with diabetes (p=0.016). Patients with diabetes had an increased length-of-stay compared to those without diabetes, which was more evident in those aged ≤60 years. Conclusion Age is the most important predictor of mortality. Patients with diabetes did not have increased mortality from COVID-19, which is likely due to their younger age in our cohort. More patients with diabetes stayed in the hospital longer than seven days than those without diabetes.
目的 本研究旨在比较确诊为 COVID-19 的糖尿病患者和非糖尿病患者的临床特征及预后（死亡率、入住重症监护病房、机械通气和住院时间）。方法 这项回顾性研究评估了 2020 年 3 月 10 日至 2020 年 6 月 30 日期间布莱顿和萨塞克斯大学医院国民保健服务信托基金的成年住院患者中实验室确诊为 COVID-19 的临床和实验室变量。进行单因素和多因素分析以比较糖尿病患者和非糖尿病患者的预后。结果 本研究纳入了 457 多名患者（140 名糖尿病患者和 317 名非糖尿病患者），其中 143 名（31.9%）死亡。中位年龄为 80 岁，主要为男性（59.1%）。COVID-19 诊断时的基线特征表明，糖尿病患者比非糖尿病患者年轻（p=0.008）。死亡率随年龄增加。糖尿病患者和非糖尿病患者的不良预后没有差异。然而，对年龄≤60 岁的患者进行亚组分析显示，糖尿病患者的死亡率显著增加（p=0.016）。与非糖尿病患者相比，糖尿病患者的住院时间更长，在年龄≤60 岁的患者中更为明显。结论 年龄是死亡率的最重要预测因素。糖尿病患者的 COVID-19 死亡率没有增加，这可能是由于我们队列中他们年龄较小。与非糖尿病患者相比，更多糖尿病患者住院时间超过七天。
