Department of General, Visceral and Vascular Surgery, University Hospital Jena, Erlanger Allee 101, 07740, Jena, Germany.
Department of General, Visceral Surgery, Zentralklinik Bad Berka, Robert-Koch-Allee 9, 99438, Bad Berka, Germany.
J Cancer Res Clin Oncol. 2022 Feb;148(2):503-515. doi: 10.1007/s00432-021-03631-5. Epub 2021 Apr 20.
In the literature, results after surgical treatment of non-colorectal non-neuroendocrine liver metastases (NCNNLM) are reported that are often inferior to those from colorectal liver metastases. The selection of patients with favorable tumor biology is currently still a matter of discussion.
MATERIALS/METHODS: The retrospective data analysis was based on data that were collected for the multicenter study "Role of surgical treatment for non-colorectal liver metastases" in county Thuringia.
For the study, 637 patients were included from 1995 to 2018. 5 and 10-year survival of R0 resected patients were 33% and 19%, respectively. In the multi-variate analysis of the entire group, sex, timing, disease-free interval, number of metastases, R-classification as well as lymph node status of the primary lesion showed an independent statistical influence on the 5-year survival. In the group of R0 resected patients, disease-free interval, number of metastases and lymph node status of the primary lesion influenced the 5-year survival in the multi-variate analysis. In kidney malignancies, R-classification, timing and number of liver metastases were statistically significant in the multi-variate analysis of the 5-year survival, in mamma carcinomas only the R-classification.
The Adam score identifies some risk factors which influence prognosis in most but not in all tumor entities. For kidney cancer and breast cancer it can be simplified.
在文献中，报道的非结直肠神经内分泌肝转移瘤（NCNNLM）的手术治疗结果往往不如结直肠肝转移瘤。目前，选择具有良好肿瘤生物学特性的患者仍然是一个讨论的问题。
材料/方法：这项回顾性数据分析基于在图林根县为多中心研究“非结直肠肝转移的手术治疗作用”而收集的数据。
在这项研究中，1995 年至 2018 年共纳入 637 例患者。R0 切除患者的 5 年和 10 年生存率分别为 33%和 19%。在全组的多变量分析中，性别、时机、无病间期、转移灶数量、R 分类以及原发灶淋巴结状态对 5 年生存率有独立的统计学影响。在 R0 切除患者中，无病间期、转移灶数量和原发灶淋巴结状态在多变量分析中影响 5 年生存率。在肾脏恶性肿瘤中，R 分类、时机和肝转移灶数量在 5 年生存率的多变量分析中具有统计学意义，而在乳腺癌中仅 R 分类具有统计学意义。
Adam 评分确定了一些影响大多数但不是所有肿瘤实体预后的危险因素。对于肾癌和乳腺癌，可以简化。
