Sener Serpil, Karaman Ulku, Kiran Tugba Raika, Colak Cemil, Aslan Ali, Direkel Sahin
Department of Dermatology, Faculty of Medicine, Inonu University, Malatya, Turkey.
Department of Medical Parasitology, Faculty of Medicine, Ordu University, Ordu, Turkey.
Iran J Parasitol. 2020 Oct-Dec;15(4):596-601. doi: 10.18502/ijpa.v15i4.4870.
Adenosine deaminase (ADA) is an aminohydrolase involved in the catabolism of purine nucleotides and irreversibly deaminizes adenosine and deoxyadenosine to inosine and deoxyinosine. ADA enzyme deficiency results in the loss of functional properties of B and T lymphocytes. species have been reported to be transmitted between humans through close contact and to play a role in the pathogenesis of rosacea, acne vulgaris, perioral dermatitis, seborrhoeic dermatitis, micropapillary-pruritic dermatitis and blepharitis. The present study aimed to compare serum ADA levels in positive patients with the healthy control individuals.
Serum ADA levels were examined for 30 patients diagnosed with erythematotelangiectatic rosacea and 40 healthy individuals in Malatya Inonu University in 2017. Standardized skin surface biopsy (SSSB) method was used to diagnose . A significant decrease was found in the ADA levels of -positive rosacea patients when compared to the control group.
ADA levels were decreased in the -positive group. The mean ADA level in patient group was significantly lower than the mean in the control group (<0.001). There was no significant difference between the patient and control groups in terms of age and gender.
During and after treatment of -positive rosacea patients, determination of ADA levels may give more detailed information on the immune mechanisms.
腺苷脱氨酶（ADA）是一种参与嘌呤核苷酸分解代谢的氨基水解酶，可将腺苷和脱氧腺苷不可逆地脱氨生成肌苷和脱氧肌苷。ADA酶缺乏会导致B淋巴细胞和T淋巴细胞功能特性丧失。据报道，某些物种可通过密切接触在人与人之间传播，并在酒渣鼻、寻常痤疮、口周皮炎、脂溢性皮炎、微乳头瘙痒性皮炎和睑缘炎的发病机制中起作用。本研究旨在比较阳性患者与健康对照个体的血清ADA水平。
2017年在马拉蒂亚伊诺努大学对30例诊断为红斑毛细血管扩张型酒渣鼻的患者和40例健康个体检测血清ADA水平。采用标准化皮肤表面活检（SSSB）方法诊断。与对照组相比，阳性酒渣鼻患者的ADA水平显著降低。
阳性组ADA水平降低。患者组的平均ADA水平显著低于对照组（<0.001）。患者组和对照组在年龄和性别方面无显著差异。
在阳性酒渣鼻患者治疗期间及治疗后，测定ADA水平可能会提供有关免疫机制的更详细信息。
