Yuan Chao, Zheng Shu-Li, Ma Ya Feng, Philippe Juliandri, Philippe Humbert
Department of Skin & Cosmetic Research, Shanghai Skin Disease Hospital, Shanghai, China.
Department of Dermatology, Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC INSERM 1431), Besançon University Hospital; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.
Dermatoendocrinol. 2017 Oct 4;9(1):e1348444. doi: 10.1080/19381980.2017.1348444. eCollection 2017.
This study was to verify if the skin cleanser could help decrease the infection ratio of Demodex Folliculorum in acne patients. 132 participants with mild to moderate vulgaris acne participated in this monocentric, prospective, double-blind study. Dermatologists grading and Standardized Skin Surface Biopsy were performed in baseline and after using cleanser only 7 d later. There was no significant difference between the 2 times for each type of acne, but the number of Demodex Folliculorum was significantly decreased compared with baseline. There was no relationship between the number of Demodex Folliculorum and the total number of acne lesions. Short follow-up time in 7 d. Using the cleanser could decrease the average number of Demodex Folliculorum in only 7 d in mild to moderate acne patients. There is no relationship between Demodex and acne lesions number.
本研究旨在验证该皮肤清洁剂是否有助于降低痤疮患者毛囊蠕形螨的感染率。132名轻至中度寻常痤疮患者参与了这项单中心、前瞻性、双盲研究。在基线时以及仅使用清洁剂7天后，由皮肤科医生进行分级并进行标准化皮肤表面活检。每种类型的痤疮在两个时间点之间没有显著差异，但与基线相比，毛囊蠕形螨的数量显著减少。毛囊蠕形螨的数量与痤疮皮损总数之间没有关系。随访时间仅7天。在轻至中度痤疮患者中，使用该清洁剂仅7天就能降低毛囊蠕形螨的平均数量。毛囊蠕形螨与痤疮皮损数量之间没有关系。
