Dipartimento Pediatrico Universitario Ospedaliero, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Childhood Cancer Research Unit, Department of Women's and Children's Health, NORDFERTIL Research Laboratory Stockholm, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.
Horm Res Paediatr. 2020;93(11-12):599-608. doi: 10.1159/000516087. Epub 2021 Apr 22.
The increasing cure rate of cancer has led to a vast population of survivors having to face the late adverse effects of oncological treatments, with fertility impairment being one of the most sensitive issues for patients. Different options to preserve the fertility of adult patients are routinely used in clinical practice. However, fertility preservation strategies for prepubertal patients at risk of infertility are limited to the cryopreservation of immature gonadal tissue. In recent decades, many research efforts have been focused on the future use of cryopreserved gonadal tissue. This review discusses the common status of fertility preservation measures for pediatric patients undergoing gonadotoxic treatment, focusing especially on the challenges that remain to be solved in order to implement this fundamental service.
癌症治愈率的提高导致大量幸存者不得不面对肿瘤治疗的晚期不良反应，而生育能力损害是患者最敏感的问题之一。在临床实践中，通常会使用不同的方法来保留成年患者的生育能力。然而，对于有不孕风险的青春期前患者，生育力保存策略仅限于不成熟性腺组织的冷冻保存。在过去的几十年中，许多研究都集中在未来对冷冻保存的性腺组织的使用上。这篇综述讨论了接受性腺毒性治疗的儿科患者常见的生育力保存措施的现状，特别是讨论了为实施这一基本服务仍需解决的挑战。
