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姜黄素促进糖尿病伤口愈合的作用及机制研究进展

[Research advances on the effects and mechanism of curcumin in promoting diabetic wound healing].

作者信息

Tu Z L, Lin C

机构信息

Department of Burns, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

出版信息

Zhonghua Shao Shang Za Zhi. 2021 Apr 20;37(4):391-394. doi: 10.3760/cma.j.cn501120-20200224-00089.

DOI:10.3760/cma.j.cn501120-20200224-00089
PMID:33887887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11917206/
Abstract

Diabetic wound is a common complication of diabetes, and the effect of current treatment is still poor. Curcumin has many pharmacological effects, such as anti-inflammatory, anti-oxidation, antimicrobial, anti-cancer, and improving insulin resistance. In this paper, the research advances on the effects and mechanism of curcumin in promoting diabetic wound healing were mainly reviewed.

摘要

糖尿病伤口是糖尿病的常见并发症,目前的治疗效果仍然不佳。姜黄素具有多种药理作用,如抗炎、抗氧化、抗菌、抗癌以及改善胰岛素抵抗。本文主要综述了姜黄素在促进糖尿病伤口愈合方面的作用及机制的研究进展。

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[Research advances on the effects and mechanism of curcumin in promoting diabetic wound healing].姜黄素促进糖尿病伤口愈合的作用及机制研究进展
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2
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Anti-Inflammatory, Wound Healing, and Anti-Diabetic Effects of Pure Active Compounds Present in the Ryudai Gold Variety of .乳蓟金品种中纯活性化合物的抗炎、伤口愈合和抗糖尿病作用。
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A Multifunctional, Tough, Stretchable, and Transparent Curcumin Hydrogel with Potent Antimicrobial, Antioxidative, Anti-inflammatory, and Angiogenesis Capabilities for Diabetic Wound Healing.一种具有多功能、坚韧、可拉伸且透明的姜黄素水凝胶,具有强大的抗菌、抗氧化、抗炎和血管生成能力,用于糖尿病伤口愈合。
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Curcumin-release antibacterial dressings with antioxidation and anti-inflammatory function for diabetic wound healing and glucose monitoring.具有抗氧化和抗炎功能的姜黄素释放抗菌敷料用于糖尿病伤口愈合和血糖监测。
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引用本文的文献

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Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype.葛根素通过调节巨噬细胞M2极化表型促进糖尿病伤口愈合。
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Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves implanting survival in diabetic wounds.姜黄素掺入的3D生物打印甲基丙烯酰化明胶水凝胶可减少活性氧诱导的脂肪干细胞凋亡,并提高在糖尿病伤口中的植入存活率。
Burns Trauma. 2022 Mar 14;10:tkac001. doi: 10.1093/burnst/tkac001. eCollection 2022.

本文引用的文献

1
Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer.静电纺纳米纤维作为治疗糖尿病足溃疡的伤口敷料。
Asian J Pharm Sci. 2019 Mar;14(2):130-143. doi: 10.1016/j.ajps.2018.04.004. Epub 2018 May 10.
2
Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing.具有生物活性的抗炎、抗菌、抗氧化硅基纳米纤维敷料可实现皮肤肿瘤光热化疗和感染诱导的伤口愈合。
ACS Nano. 2020 Mar 24;14(3):2904-2916. doi: 10.1021/acsnano.9b07173. Epub 2020 Feb 27.
3
Topical application of curcumin regulates the angiogenesis in diabetic-impaired cutaneous wound.姜黄素的局部应用调节糖尿病损伤皮肤伤口的血管生成。
Cell Biochem Funct. 2020 Jul;38(5):558-566. doi: 10.1002/cbf.3500. Epub 2020 Feb 6.
4
Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies.姜黄素的抗糖尿病作用 II:来自体内研究的证据。
Nutrients. 2019 Dec 25;12(1):58. doi: 10.3390/nu12010058.
5
Diabetic Foot Ulcers: Appraising Standard of Care and Reviewing New Trends in Management.糖尿病足溃疡:评估标准护理并综述管理新趋势。
Am J Clin Dermatol. 2020 Apr;21(2):255-264. doi: 10.1007/s40257-019-00495-x.
6
Neuroprotective effects of curcumin through autophagy modulation.姜黄素通过自噬调节发挥神经保护作用。
IUBMB Life. 2020 Apr;72(4):652-664. doi: 10.1002/iub.2209. Epub 2019 Dec 5.
7
MMP-9 responsive dipeptide-tempted natural protein hydrogel-based wound dressings for accelerated healing action of infected diabetic wound.基于 MMP-9 响应性二肽诱导体天然蛋白水凝胶的伤口敷料,用于加速感染性糖尿病伤口的愈合作用。
Int J Biol Macromol. 2020 Jun 15;153:1058-1069. doi: 10.1016/j.ijbiomac.2019.10.236. Epub 2019 Nov 19.
8
Curcumin alleviates diabetic nephropathy via inhibiting podocyte mesenchymal transdifferentiation and inducing autophagy in rats and MPC5 cells.姜黄素通过抑制足细胞间充质转分化和诱导自噬减轻糖尿病肾病大鼠及 MPC5 细胞损伤。
Pharm Biol. 2019 Dec;57(1):778-786. doi: 10.1080/13880209.2019.1688843.
9
Curcumin and Type 2 Diabetes Mellitus: Prevention and Treatment.姜黄素与 2 型糖尿病:预防与治疗。
Nutrients. 2019 Aug 8;11(8):1837. doi: 10.3390/nu11081837.
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Enhanced wound healing by PVA/Chitosan/Curcumin patches: In vitro and in vivo study.PVA/壳聚糖/姜黄素贴剂促进伤口愈合的作用:体外和体内研究。
Colloids Surf B Biointerfaces. 2019 Oct 1;182:110339. doi: 10.1016/j.colsurfb.2019.06.068. Epub 2019 Jul 1.