Department of Cancer Epidemiology, Division of Population Science, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Dr., MRC 213, Tampa, FL, 33612, USA.
Medical Research Council - Cancer Unit, Division of Clinical Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
BMC Public Health. 2021 Apr 23;21(1):692. doi: 10.1186/s12889-021-10424-5.
Individuals from melanoma-prone families have similar or reduced sun-protective behaviors compared to the general population. Studies on trends in sun-related behaviors have been temporally and geographically limited.
Individuals from an international consortium of melanoma-prone families (GenoMEL) were retrospectively asked about sunscreen use, sun exposure (time spent outside), sunburns, and sunbed use at several timepoints over their lifetime. Generalized linear mixed models were used to examine the association between these outcomes and birth cohort defined by decade spans, after adjusting for covariates.
A total of 2407 participants from 547 families across 17 centers were analyzed. Sunscreen use increased across subsequent birth cohorts, and although the likelihood of sunburns increased until the 1950s birth cohort, it decreased thereafter. Average sun exposure did not change across the birth cohorts, and the likelihood of sunbed use increased in more recent birth cohorts. We generally did not find any differences in sun-related behavior when comparing melanoma cases to non-cases. Melanoma cases had increased sunscreen use, decreased sun exposure, and decreased odds of sunburn and sunbed use after melanoma diagnosis compared to before diagnosis.
Although sunscreen use has increased and the likelihood of sunburns has decreased in more recent birth cohorts, individuals in melanoma-prone families have not reduced their overall sun exposure and had an increased likelihood of sunbed use in more recent birth cohorts. These observations demonstrate partial improvements in melanoma prevention and suggest that additional intervention strategies may be needed to achieve optimal sun-protective behavior in melanoma-prone families.
与普通人群相比，来自黑色素瘤高发家族的个体具有相似或减少的防晒行为。关于与太阳有关的行为趋势的研究在时间和地理上受到限制。
国际黑色素瘤高发家族联盟（GenoMEL）的个体被回顾性地询问了一生中几个时间点的防晒霜使用、日晒时间（在户外度过的时间）、晒伤和晒黑床使用情况。使用广义线性混合模型，在调整了协变量后，研究了这些结果与出生队列（以十年跨度定义）之间的关联。
共分析了来自 17 个中心的 547 个家族的 2407 名参与者。防晒霜的使用随着后续出生队列的增加而增加，尽管直到 20 世纪 50 年代出生队列，晒伤的可能性增加，但此后有所减少。平均日晒时间在出生队列中没有变化，而最近出生队列中使用晒黑床的可能性增加。当比较黑色素瘤病例与非病例时，我们通常没有发现与太阳有关的行为有任何差异。与诊断前相比，黑色素瘤病例在诊断后增加了防晒霜的使用，减少了日晒，减少了晒伤和晒黑床使用的几率。
尽管最近出生队列中防晒霜的使用有所增加，晒伤的可能性有所降低，但黑色素瘤高发家族的个体并未减少其总体日晒量，并且在最近的出生队列中使用晒黑床的可能性增加。这些观察结果表明黑色素瘤预防措施有所改善，并表明可能需要额外的干预策略，以在黑色素瘤高发家族中实现最佳的防晒行为。
