Blanquart Eve, Laffont Sophie, Guéry Jean-Charles
Physiopathology Center of Toulouse-Purpan (CPTP), University of Toulouse, INSERM, CNRS, UPS, 31300, France.
Physiopathology Center of Toulouse-Purpan (CPTP), University of Toulouse, INSERM, CNRS, UPS, 31300, France.
Biomed J. 2021 Apr;44(2):144-156. doi: 10.1016/j.bj.2020.11.007. Epub 2020 Nov 18.
Innate lymphoid cell (ILC) subsets at barrier surfaces contribute to maintain tissue homeostasis and appropriate responses to infection. ILCs respond to environmental factors produced by non-hematopoietic cells within tissues, but also circulating cytokines or dietary compounds which allow them to adapt to organ milieu. Among these extrinsic signals, evidence is emerging that sex steroid hormones may act in a cell-intrinsic manner to regulate the development, maintenance in tissues and effector functions of specific subsets of ILCs. Understanding the nature and molecular mechanisms of sex steroid hormone actions on ILCs is important to unravel the cause of sexual disparity in human diseases and could lead to new drug development for the treatment of chronic inflammatory diseases or cancers. This review discusses the recent development in our understanding of the cell-intrinsic actions of sex steroid hormones on ILCs and their consequences on tissue-specific immunity with a particular focus on group 2 innate lymphoid cells and NK cells.
屏障表面的固有淋巴细胞（ILC）亚群有助于维持组织稳态以及对感染作出适当反应。ILC对组织内非造血细胞产生的环境因子作出反应，也对循环细胞因子或饮食化合物作出反应，这些因子使它们能够适应器官微环境。在这些外在信号中，越来越多的证据表明，性类固醇激素可能以细胞内在方式发挥作用，调节特定ILC亚群的发育、在组织中的维持以及效应功能。了解性类固醇激素对ILC作用的性质和分子机制，对于揭示人类疾病中性别差异的原因至关重要，并可能引领治疗慢性炎症性疾病或癌症的新药研发。本综述讨论了我们对性类固醇激素对ILC的细胞内在作用及其对组织特异性免疫影响的最新认识进展，特别关注2型固有淋巴细胞和自然杀伤细胞。
