Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Sector-12, Chandigarh, 160012, India.
Mycopathologia. 2024 Oct 3;189(6):90. doi: 10.1007/s11046-024-00893-8.
The impact of sex on allergic bronchopulmonary aspergillosis (ABPA) outcomes remains uncertain. We retrospectively included ABPA subjects per the revised International Society for Human and Animal Mycology ABPA working group criteria over 13 years. We compared the clinical features, lung function, immunological tests, imaging, and ABPA exacerbation rates between men and women. Our primary objective was to assess whether women experience higher ABPA exacerbations than men. We included 731 ABPA subjects (mean age, 34.5 years; 49.5% women). Women with ABPA were older and had underlying asthma more frequently than men. There was no difference in lung function, immunological investigations, and imaging between men and women. ABPA exacerbations occurred in a slightly higher proportion of women than men (44.5% vs. 38.2%) but did not reach statistical significance (p = 0.09). We did not find a significant sex difference in ABPA exacerbation rates. Prospective studies should confirm our findings.
性别对变应性支气管肺曲霉病（ABPA）结局的影响尚不确定。我们回顾性纳入了 13 年来符合修订后的国际人类和动物真菌学会 ABPA 工作组标准的 ABPA 患者。我们比较了男性和女性之间的临床特征、肺功能、免疫学检查、影像学和 ABPA 加重率。我们的主要目的是评估女性是否比男性经历更高的 ABPA 加重。我们纳入了 731 名 ABPA 患者（平均年龄 34.5 岁；49.5%为女性）。ABPA 女性比男性年龄更大且更常患有基础哮喘。男性和女性之间的肺功能、免疫学检查和影像学没有差异。ABPA 加重的女性比例略高于男性（44.5%比 38.2%），但无统计学意义（p=0.09）。我们没有发现 ABPA 加重率存在显著的性别差异。需要前瞻性研究来证实我们的发现。
