PCOS and Inositols: Controversial Results and Necessary Clarifications. Basic Differences Between D-Chiro and Myo-Inositol.
作者信息
Monastra Giovanni, Vucenik Ivana, Harrath Abdel Halim, Alwasel Saleh H, Kamenov Zdravko A, Laganà Antonio Simone, Monti Noemi, Fedeli Valeria, Bizzarri Mariano
机构信息
Systems Biology Group Lab (SBGLab), Sapienza University, Rome, Italy.
Department of Medical and Research Technology, University of Maryland School of Medicine, Baltimore, MD, United States.
出版信息
Front Endocrinol (Lausanne). 2021 Apr 6;12:660381. doi: 10.3389/fendo.2021.660381. eCollection 2021.
Abstract
摘要
相似文献
1
PCOS and Inositols: Controversial Results and Necessary Clarifications. Basic Differences Between D-Chiro and Myo-Inositol.多囊卵巢综合征与肌醇：有争议的结果及必要的阐释。D-手性肌醇与肌醇之间的基本差异
Front Endocrinol (Lausanne). 2021 Apr 6;12:660381. doi: 10.3389/fendo.2021.660381. eCollection 2021.
2
The use of inositol(s) isomers in the management of polycystic ovary syndrome: a comprehensive review.肌醇异构体在多囊卵巢综合征管理中的应用：一项综述
Gynecol Endocrinol. 2018 Jul;34(7):545-550. doi: 10.1080/09513590.2017.1421632. Epub 2018 Jan 8.
3
Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome.多囊卵巢综合征治疗中肌醇/d-手性肌醇联合应用的研究进展。
Gynecol Endocrinol. 2024 Dec;40(1):2301554. doi: 10.1080/09513590.2023.2301554. Epub 2024 Jan 18.
4
Inositols: From Established Knowledge to Novel Approaches.肌醇：从已有知识到新方法。
Int J Mol Sci. 2021 Sep 30;22(19):10575. doi: 10.3390/ijms221910575.
5
Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis.口服胰岛素增敏剂二甲双胍、噻唑烷二酮类、肌醇和小檗碱改善多囊卵巢综合征女性内分泌和代谢谱的疗效比较：网络荟萃分析。
Reprod Health. 2021 Aug 18;18(1):171. doi: 10.1186/s12978-021-01207-7.
6
D-Chiro-inositol and PCOS: between myth and reality. The never-ending story.D-手性肌醇与多囊卵巢综合征：介于神话与现实之间。永无休止的故事。
Int J Food Sci Nutr. 2022 Aug;73(5):565-570. doi: 10.1080/09637486.2022.2029830. Epub 2022 Jan 20.
7
8
Inositols' Importance in the Improvement of the Endocrine-Metabolic Profile in PCOS.肌醇在多囊卵巢综合征患者内分泌代谢特征改善中的重要性。
Int J Mol Sci. 2019 Nov 18;20(22):5787. doi: 10.3390/ijms20225787.
9
Updates on the myo-inositol plus D-chiro-inositol combined therapy in polycystic ovary syndrome.多囊卵巢综合征中肌醇加D-手性肌醇联合治疗的研究进展
Expert Rev Clin Pharmacol. 2014 Sep;7(5):623-31. doi: 10.1586/17512433.2014.925795. Epub 2014 Jun 5.
10
Myo-inositol in assisted reproductive technology from bench to bedside.辅助生殖技术中肌醇从实验台到病床边的应用
Trends Endocrinol Metab. 2024 Jan;35(1):74-83. doi: 10.1016/j.tem.2023.09.005. Epub 2023 Oct 3.
引用本文的文献
1
PCOS and Inositols - Advances and Lessons We are Learning. A Narrative Review.多囊卵巢综合征与肌醇——我们正在汲取的进展与经验。一篇叙述性综述。
Drug Des Devel Ther. 2025 May 21;19:4183-4199. doi: 10.2147/DDDT.S524718. eCollection 2025.
2
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method.一种新开发的液相色谱-质谱法揭示的细胞肌醇代谢的基本特征。
Biochem J. 2025 May 13;482(11):675-90. doi: 10.1042/BCJ20253028.
3
D-chiro-inositol effectively counteracts endometriosis in a mouse model.D-手性肌醇在小鼠模型中可有效对抗子宫内膜异位症。
Mol Med. 2025 Apr 11;31(1):134. doi: 10.1186/s10020-025-01178-6.
4
Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential.天然化合物在多囊卵巢综合征管理中的应用：激素调节与治疗潜力的全面综述
Front Nutr. 2025 Feb 11;12:1520695. doi: 10.3389/fnut.2025.1520695. eCollection 2025.
5
Inositol Restores Appropriate Steroidogenesis in PCOS Ovaries Both In Vitro and In Vivo Experimental Mouse Models.肌醇可恢复多囊卵巢综合征卵巢的适当类固醇生成，无论是在体外还是体内实验性小鼠模型中。
Cells. 2024 Jul 9;13(14):1171. doi: 10.3390/cells13141171.
6
Inositols and female reproduction disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)-Women's Endocrinology.肌醇与女性生殖障碍：意大利内分泌学会（SIE）-女性内分泌学工作组的共识声明。
J Endocrinol Invest. 2024 Sep;47(9):2111-2141. doi: 10.1007/s40618-024-02363-w. Epub 2024 Jul 15.
7
<sc>d</sc>-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI).《临床实践中的 D-手性肌醇：基础与临床研究手性肌醇专家组（EGOI）的观点》。
Gynecol Obstet Invest. 2024;89(4):284-294. doi: 10.1159/000536081. Epub 2024 Feb 19.
8
Stereoselective Voltammetric Biosensor for Myo-Inositol and D-Chiro-Inositol Recognition.手性立体选择伏安生物传感器用于肌醇和 D-手性肌醇的识别。
Sensors (Basel). 2023 Nov 16;23(22):9211. doi: 10.3390/s23229211.
9
D-Chiro-Inositol in Endometrial Hyperplasia: A Pilot Study.地胆草素在子宫内膜增生中的作用：一项初步研究。
Int J Mol Sci. 2023 Jun 13;24(12):10080. doi: 10.3390/ijms241210080.
10
The Role of Inositols in the Hyperandrogenic Phenotypes of PCOS: A Re-Reading of Larner's Results.多囊卵巢综合征高雄激素表型中肌醇的作用：重新解读拉纳的研究结果。
Int J Mol Sci. 2023 Mar 27;24(7):6296. doi: 10.3390/ijms24076296.
本文引用的文献
1
The use of D-chiro-Inositol in clinical practice.在临床实践中使用 D-手性肌醇。
Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):438-446. doi: 10.26355/eurrev_202101_24412.
2
Inositols: reflections on how to choose the appropriate one for PCOS.肌醇：关于如何为多囊卵巢综合征选择合适肌醇的思考
Gynecol Endocrinol. 2020 Dec;36(12):1045-1046. doi: 10.1080/09513590.2020.1846697. Epub 2020 Nov 10.
3
Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions.多囊卵巢综合征的基本概念与新进展：专家共识决议
Front Endocrinol (Lausanne). 2020 Aug 11;11:516. doi: 10.3389/fendo.2020.00516. eCollection 2020.
4
New clinical targets of d-chiro-inositol: rationale and potential applications.d-手性肌醇的新临床靶点：原理与潜在应用
Expert Opin Drug Metab Toxicol. 2020 Aug;16(8):703-710. doi: 10.1080/17425255.2020.1785429. Epub 2020 Jul 9.
5
Inositols in Polycystic Ovary Syndrome: An Overview on the Advances.多囊卵巢综合征中的肌醇：研究进展概述。
Trends Endocrinol Metab. 2020 Jun;31(6):435-447. doi: 10.1016/j.tem.2020.02.002. Epub 2020 Mar 9.
6
Risk of reduced intestinal absorption of myo-inositol caused by D-chiro-inositol or by glucose transporter inhibitors.D-手性肌醇或葡萄糖转运体抑制剂导致肌醇肠道吸收减少的风险。
Expert Opin Drug Metab Toxicol. 2019 Sep;15(9):697-703. doi: 10.1080/17425255.2019.1651839. Epub 2019 Aug 8.
7
The 40:1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios.40:1 肌醇/D-手性肌醇血浆比值能够恢复多囊卵巢综合征患者的排卵：与其他比值的比较。
Eur Rev Med Pharmacol Sci. 2019 Jun;23(12):5512-5521. doi: 10.26355/eurrev_201906_18223.
8
Myo-inositol and D-chiro-inositol (40:1) reverse histological and functional features of polycystic ovary syndrome in a mouse model.肌醇和 D-手性肌醇（40:1）逆转了多囊卵巢综合征小鼠模型的组织学和功能特征。
J Cell Physiol. 2019 Jun;234(6):9387-9398. doi: 10.1002/jcp.27623. Epub 2018 Oct 14.
9
Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach.多囊卵巢综合征中的肌醇：基于病理生理学的方法恢复生育能力。
Trends Endocrinol Metab. 2018 Nov;29(11):768-780. doi: 10.1016/j.tem.2018.09.001. Epub 2018 Sep 27.
10
Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials.补充肌醇可减少接受体外受精女性的促性腺激素量及卵巢刺激时间：一项随机对照试验的系统评价和荟萃分析
Arch Gynecol Obstet. 2018 Oct;298(4):675-684. doi: 10.1007/s00404-018-4861-y. Epub 2018 Aug 4.
Zotero 插件