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本文引用的文献

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Genetics of anophthalmia and microphthalmia. Part 1: Non-syndromic anophthalmia/microphthalmia.先天性无眼症和小眼球症的遗传学。第 1 部分:非综合征性先天性无眼症/小眼球症。
Hum Genet. 2019 Sep;138(8-9):799-830. doi: 10.1007/s00439-019-01977-y. Epub 2019 Feb 14.
2
Prevalence of Congenital Ocular Anomalies among Children with Genetic Disorders: An Egyptian Study.遗传疾病患儿先天性眼部异常的患病率:一项埃及研究。
Semin Ophthalmol. 2018;33(5):613-619. doi: 10.1080/08820538.2017.1375124. Epub 2017 Oct 9.
3
The Evaluation of Red Reflex Sensitivity and Specificity Test among Neonates in Different Conditions.不同条件下新生儿红色反射敏感性和特异性测试的评估
Iran J Pediatr. 2014 Dec;24(6):697-702. Epub 2014 Nov 7.
4
Prevalence of congenital eye anomalies in a paediatric clinic in Ghana.
East Mediterr Health J. 2014 Jan 9;19 Suppl 3:S76-80.
5
Spectrum of congenital defects of the eye and its adnexia in the pediatric age group; experience at a tertiary facility in Nigeria.小儿年龄组眼部及其附属器先天性缺陷的谱系;尼日利亚一家三级医疗机构的经验。
Int Ophthalmol. 2015 Jun;35(3):311-7. doi: 10.1007/s10792-014-9946-4. Epub 2014 Apr 18.
6
Eye malformations in Cameroonian children: a clinical survey.
Clin Ophthalmol. 2012;6:1607-11. doi: 10.2147/OPTH.S36475. Epub 2012 Oct 4.
7
The red reflex examination in neonates: an efficient tool for early diagnosis of congenital ocular diseases.新生儿的红光反射检查:先天性眼病早期诊断的有效工具。
Isr Med Assoc J. 2010 May;12(5):259-61.
8
Molecular characteristics of inherited congenital cataracts.遗传性先天性白内障的分子特征
Eur J Med Genet. 2010 Nov-Dec;53(6):347-57. doi: 10.1016/j.ejmg.2010.07.001. Epub 2010 Sep 17.
9
Importance of gene-environment interactions in the etiology of selected birth defects.基因-环境相互作用在特定出生缺陷病因学中的重要性。
Clin Genet. 2009 May;75(5):409-23. doi: 10.1111/j.1399-0004.2009.01174.x.
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[Congenital glaucoma at CNHU in Cotonou: a review of 27 cases].
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[多哥洛美大学医院校区的先天性眼部异常]

[Congenital ocular anomalies at the University Hospital Campus in Lomé, Togo].

作者信息

Diatewa Bénédicte Marèbe, Maneh Nidain, Domingo Aboubakr Sidik, Gnansa Koboyo Esso-Issinam, Ayikoue Yannick Francis Amah, Balo Komi Patrice

机构信息

Service d´Ophtalmologie, Centre Hospitalier Universitaire, Campus de Lomé, Lomé, Togo.

Université de Lomé, Faculté des Sciences de la Santé, Lomé, Togo.

出版信息

Pan Afr Med J. 2021 Jan 22;38:79. doi: 10.11604/pamj.2021.38.79.21757. eCollection 2021.

DOI:10.11604/pamj.2021.38.79.21757
PMID:33889245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8033191/
Abstract

INTRODUCTION

congenital ocular anomalies are rare clinical entities. The purpose of this study is to describe the epidemiological and clinical features of congenital ocular anomalies at the University Hospital Campus in Lomé.

METHODS

we conducted a retrospective study at the Department of Ophthalmology of the University Hospital Campus in Lomé, over a 3-year period, from January 2016 to December 2018. It involved children with congenital ocular anomalies. The study variables were: sex; age at diagnosis; type of congenital ocular anomalies; laterality.

RESULTS

out of 2621 children assessed during the study period, 103 (3.9%) had congenital ocular anomalies. Of these, 60 (58.2%) were boys and 43 (41.8%) girls. The average age at diagnosis was 16 ± 5.2 months (ranging from 1 months to 5 years). The most common congenital ocular anomaly was cataract (53.4%). Unilateral alterations were predominant (56.3%). Congenital ocular anomalies were isolated (82.5%); associated with systemic anomalies (11.7%); associated with each other (5.8%).

CONCLUSION

these results show that the epidemiological and clinical features of congenital ocular anomalies are similar to those reported in the literature. However, in our Hospital, the frequency of congenital ocular anomalies and patients' age at diagnosis are high. Early diagnosis is essential to ensure adequate management and preserve visual function.

摘要

引言

先天性眼部异常是罕见的临床病症。本研究的目的是描述洛美大学校园医院先天性眼部异常的流行病学和临床特征。

方法

我们在洛美大学校园医院眼科进行了一项回顾性研究,为期3年,从2016年1月至2018年12月。研究对象为患有先天性眼部异常的儿童。研究变量包括:性别;诊断时的年龄;先天性眼部异常的类型;病变侧别。

结果

在研究期间评估的2621名儿童中,103名(3.9%)患有先天性眼部异常。其中,60名(58.2%)为男孩,43名(41.8%)为女孩。诊断时的平均年龄为16±5.2个月(范围从1个月至5岁)。最常见的先天性眼部异常是白内障(53.4%)。单侧病变为主(56.3%)。先天性眼部异常为孤立性的(82.5%);与全身异常相关的(11.7%);相互关联的(5.8%)。

结论

这些结果表明,先天性眼部异常的流行病学和临床特征与文献报道的相似。然而,在我们医院,先天性眼部异常的发生率和患者诊断时的年龄较高。早期诊断对于确保适当的治疗和保留视功能至关重要。