Biology of Development and Differentiation Laboratory, Oran 1 University, Ahmed Ben Bella, Oran, Algeria.
Faculty of Medicine, Oran 1 University, Ahmed Ben Bella, Oran, Algeria.
Pan Afr Med J. 2021 Jan 27;38:88. doi: 10.11604/pamj.2021.38.88.21370. eCollection 2021.
breast cancer is related to age. The young age remains a controversial issue as a prognostic factor and have more aggressive clinical behavior with poor outcome. We aimed for the first time in Algeria to explore on a large cohort of patients the prevalence of the molecular phenotypes and to describe their clinical characteristics and survival.
medical record of 1140 Algerian patients were analysed and categorized into three age groups: "young" when women were aged below 40 years; "middle-age" when women were aged from 41 to 54 years old and "elder" when women were over 54 years. Baseline categorical variables were analysed using the Chi-square test and survival curves were constructed using Kaplan Meir method.
the distribution of the various prognostic factors did not differ significativelly by age groups except for histological types, hormone receptors status and molecular phenotypes. Most patients were luminal A, indeed, young and intermediate age patients were most likely to be luminal A whereas the aged patients were triple negative with the highest mean DFS. Elsewhere young women are considered as human epidermal growth factor receptor 2 (HER2+) or triple negative molecular subtypes involving more rigorous therapeutic monitoring. The high rate of triple negative breast cancer in aged patients may due to genetic predispositions.
this study sheds light on the histoclinical and molecular characteristics of breast cancer in young patients, which has a good prognosis than their older counterparts. Our results are therefore surprisingly different from what the literature suggests. A further study should understand this uncommon finding.
乳腺癌与年龄有关。年轻的年龄仍然是一个有争议的预后因素，并具有更具侵袭性的临床行为和较差的结局。我们首次在阿尔及利亚探索了大量患者的分子表型的流行情况，并描述了他们的临床特征和生存情况。
分析了 1140 名阿尔及利亚患者的病历，并将其分为三组年龄：“年轻”是指女性年龄低于 40 岁；“中年”是指女性年龄在 41 至 54 岁之间；“老年”是指女性年龄超过 54 岁。使用卡方检验分析基线分类变量，使用 Kaplan-Meier 方法构建生存曲线。
除了组织学类型、激素受体状态和分子表型外，各预后因素的分布在年龄组之间无显著差异。大多数患者是 luminal A 型，事实上，年轻和中年患者最有可能是 luminal A 型，而老年患者则是三阴性，DFS 最高。此外，年轻女性被认为是人类表皮生长因子受体 2（HER2+）或三阴性分子亚型，需要更严格的治疗监测。老年患者中三阴性乳腺癌的高发生率可能与遗传易感性有关。
本研究揭示了年轻患者乳腺癌的组织临床和分子特征，其预后优于年长患者。我们的结果与文献所表明的结果惊人地不同。进一步的研究应该理解这种不常见的发现。
