National Cancer Institute, Ministry of Health, Kyiv, Ukraine.
Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine.
J Med Life. 2023 Jan;16(1):70-75. doi: 10.25122/jml-2022-0189.
We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype.
我们旨在分析乳腺癌复发的频率及其与分子和生物学肿瘤特征的关系。我们研究了 6136 例乳腺癌患者，其中 146 例复发（第 1 组），455 例未复发（第 2 组）。我们根据年龄、月经功能、疾病分期、组织学形式和分级以及分子生物学亚型对患者进行分组。第 1 组的 5 年无复发生存率 Lum A 和 TN 亚型较长（分别为 60%和 40%），但 Lum B 和 HER-2/neu 扩增亚型较短（分别为 38%和 31%）。疾病分期、肿瘤组织学和分级对这些患者的复发频率没有显著影响。在绝经前患者和 Lum B 亚型中，复发更为常见。
