Ata Fateen, Marzouk Sandy Kamil Kamal, Bilal Ammara Bint I, Khan Adeel Ahmed, Ibrahim Ezzedin, Almadani Mohammed Taha Mahmood
Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
College of Medicine, Qatar University, Qatar.
IDCases. 2021 Mar 31;24:e01103. doi: 10.1016/j.idcr.2021.e01103. eCollection 2021.
Typhi (ST) is a rod-shaped gram-negative bacterium that infects humans via contaminated food or water. Humans are the only reservoirs for the bacteria. Infection usually manifests as fever, abdominal pain, and diarrhea. However, complications such as intestinal perforation, hepatosplenomegaly, and renal injury can occasionally occur. Acute kidney injury (AKI) is associated more commonly with ST than other bacteria causing gastrointestinal (GI) infections. The exact pathophysiology of AKI in ST infection is unknown. One of the rarely reported mechanisms is rhabdomyolysis. We present a similar case of resistant ST infection leading to AKI with rhabdomyolysis. This article also contains an extensive literature reviews of all reported ST bacteremia cases with AKI secondary to rhabdomyolysis.
伤寒沙门氏菌（ST）是一种杆状革兰氏阴性菌，可通过受污染的食物或水感染人类。人类是该细菌的唯一宿主。感染通常表现为发热、腹痛和腹泻。然而，偶尔也会出现诸如肠穿孔、肝脾肿大和肾损伤等并发症。与其他引起胃肠道（GI）感染的细菌相比，急性肾损伤（AKI）在ST感染中更为常见。ST感染中AKI的确切病理生理学尚不清楚。横纹肌溶解是一种罕见报道的机制之一。我们报告了一例类似的耐ST感染导致AKI并伴有横纹肌溶解的病例。本文还对所有报道的继发于横纹肌溶解的ST菌血症合并AKI病例进行了广泛的文献综述。
