Neonatal jaundice in cystic fibrosis: a conservative approach is not always justified.

Biliary obstruction due to cystic fibrosis is considered to be reversible and conservative management is recommended. We present two cases of cystic fibrosis with anatomic lesions of the extrahepatic bile ducts, necessitating operative correction. In the management of prolonged neonatal jaundice in cystic fibrosis, a conservative approach is frequently successful, but in some cases surgical intervention may be mandatory.