人生早期全氟烷基物质暴露与葡萄糖稳态标志物的关系。
Life-course Exposure to Perfluoroalkyl Substances in Relation to Markers of Glucose Homeostasis in Early Adulthood.
机构信息
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
J Clin Endocrinol Metab. 2021 Jul 13;106(8):2495-2504. doi: 10.1210/clinem/dgab267.
OBJECTIVE
To investigate the prospective associations of life-course perfluoroalkyl substances (PFASs) exposure with glucose homeostasis at adulthood.
METHODS
We calculated insulin sensitivity and beta-cell function indices based on 2-h oral glucose tolerance tests at age 28 in 699 Faroese born in 1986-1987. Five major PFASs were measured in cord whole blood and in serum from ages 7, 14, 22, and 28 years. We evaluated the associations with glucose homeostasis measures by PFAS exposures at different ages using multiple informant models fitting generalized estimating equations and by life-course PFAS exposures using structural equation models.
RESULTS
Associations were stronger for perfluorooctane sulfonate (PFOS) and suggested decreased insulin sensitivity and increased beta-cell function-for example, β (95% CI) for log-insulinogenic index per PFOS doubling = 0.12 (0.02, 0.22) for prenatal exposures, 0.04 (-0.10, 0.19) at age 7, 0.07 (-0.07, 0.21) at age 14, 0.05 (-0.04, 0.15) at age 22, and 0.04 (-0.03, 0.11) at age 28. Associations were consistent across ages (P for age interaction > 0.10 for all PFASs) and sex (P for sex interaction > 0.10 for all PFASs, except perfluorodecanoic acid). The overall life-course PFOS exposure was also associated with altered glucose homeostasis (P = 0.04). Associations for other life-course PFAS exposures were nonsignificant.
CONCLUSIONS
Life-course PFAS exposure is associated with decreased insulin sensitivity and increased pancreatic beta-cell function in young adults.
目的
研究一生中全氟烷基物质（PFAS）暴露与成年期葡萄糖稳态的前瞻性关联。
方法
我们根据 1986-1987 年出生的 699 名法罗群岛人的 28 岁 2 小时口服葡萄糖耐量试验，计算了胰岛素敏感性和胰岛β细胞功能指数。在脐带全血和 7、14、22 和 28 岁时的血清中测量了 5 种主要的 PFAS。我们通过使用广义估计方程拟合的多信息模型和使用结构方程模型的生活过程 PFAS 暴露，评估了不同年龄的 PFAS 暴露与葡萄糖稳态测量之间的相关性。
结果
对于全氟辛烷磺酸（PFOS），相关性更强，表明胰岛素敏感性降低，胰岛β细胞功能增加-例如，PFOS 倍增的对数胰岛素生成指数的β（95%置信区间）为 0.12（0.02，0.22）在产前暴露中，在 7 岁时为 0.04（-0.10，0.19），在 14 岁时为 0.07（-0.07，0.21），在 22 岁时为 0.05（-0.04，0.15），在 28 岁时为 0.04（-0.03，0.11）。在所有 PFAS 中，各年龄段（所有 PFAS 的年龄交互作用 P>0.10）和性别（所有 PFAS 的性别交互作用 P>0.10，除了全氟癸酸）的相关性都一致。整个生命周期的 PFOS 暴露也与葡萄糖稳态的改变有关（P=0.04）。其他生活过程中 PFAS 暴露的相关性没有统计学意义。
结论
一生中的 PFAS 暴露与年轻成年人的胰岛素敏感性降低和胰岛β细胞功能增加有关。
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