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2021 年 3 月，德国在五种 SARS-CoV-2 快速抗原检测（RAT）中检测到新型 SARS-CoV-2 关注变异株 B.1.1.7 和 B.1.351。

Detection of the new SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in five SARS-CoV-2 rapid antigen tests (RATs), Germany, March 2021.

机构信息

Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany.

These authors contributed equally to this work.

出版信息

Euro Surveill. 2021 Apr;26(16). doi: 10.2807/1560-7917.ES.2021.26.16.2100413.

DOI:10.2807/1560-7917.ES.2021.26.16.2100413
PMID:33890568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8063588/
Abstract

SARS-CoV-2 variants of concern (VOC) should not escape molecular surveillance. We investigated if SARS-CoV-2 rapid antigen tests (RATs) could detect B.1.1.7 and B.1.351 VOCs in certain laboratory conditions. Infectious cell culture supernatants containing B.1.1.7, B.1.351 or non-VOC SARS-CoV-2 were respectively diluted both in DMEM and saliva. Dilutions were analysed with Roche, Siemens, Abbott, nal von minden and RapiGEN RATs. While further studies with appropriate real-life clinical samples are warranted, all RATs detected B.1.1.7 and B.1.351, generally comparable to non-VOC strain.

摘要

关注的 SARS-CoV-2 变异株（VOC）不应逃避分子监测。我们研究了 SARS-CoV-2 快速抗原检测（RAT）是否可以在某些实验室条件下检测到 B.1.1.7 和 B.1.351 VOC。分别含有 B.1.1.7、B.1.351 或非 VOC SARS-CoV-2 的感染细胞培养上清液在 DMEM 和唾液中分别进行稀释。罗氏、西门子、雅培、纳尔冯明登和 RapiGEN RAT 对稀释液进行了分析。虽然需要进一步研究适当的现实临床样本，但所有 RAT 均检测到 B.1.1.7 和 B.1.351，通常与非 VOC 株相当。

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本文引用的文献

[1]
Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study.

Lancet Microbe. 2021-7

[2]
Comparison of nine different commercially available molecular assays for detection of SARS-CoV-2 RNA.

Eur J Clin Microbiol Infect Dis. 2021-6

[3]
Identification and molecular characterization of mutations in nucleocapsid phosphoprotein of SARS-CoV-2.

PeerJ. 2021-1-4

[4]
The Comparative Clinical Performance of Four SARS-CoV-2 Rapid Antigen Tests and Their Correlation to Infectivity In Vitro.

J Clin Med. 2021-1-17

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Virol J. 2020-10-21

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Rethinking Covid-19 Test Sensitivity - A Strategy for Containment.

N Engl J Med. 2020-11-26

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Virological assessment of hospitalized patients with COVID-2019.

Nature. 2020-4-1

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