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可溶性（前）肾素受体缺失可减轻血管紧张素 II 诱导的高血压和肾脏损伤。

Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury.

机构信息

Division of Nephrology and Hypertension (N.R., D.S., C.S.P., C.H., W.W., D.E.K.), University of Utah Health, Salt Lake City.

Nutrition and Integrative Physiology (J.M.C., J.D.S.), University of Utah Health, Salt Lake City.

出版信息

Circ Res. 2021 Jun 25;129(1):50-62. doi: 10.1161/CIRCRESAHA.120.317532. Epub 2021 Apr 23.

DOI:10.1161/CIRCRESAHA.120.317532
PMID:33890822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8225587/
Abstract

[Figure: see text].

摘要

[图：见正文]。

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本文引用的文献

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Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F817-F825. doi: 10.1152/ajprenal.00436.2019. Epub 2019 Dec 16.
2
Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice.可溶性肾素前体受体可增加高脂喂养雄性小鼠的血压。
Hypertension. 2019 Oct;74(4):1014-1020. doi: 10.1161/HYPERTENSIONAHA.119.12906. Epub 2019 Aug 5.
3
The (pro)renin receptor in health and disease.在健康和疾病中的（前）肾素受体。
Nat Rev Nephrol. 2019 Nov;15(11):693-712. doi: 10.1038/s41581-019-0160-5.
4
Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability.站点 1 蛋白酶衍生的可溶性（前）肾素受体靶向血管加压素受体 2 以增强尿液浓缩能力。
JCI Insight. 2019 Apr 4;4(7). doi: 10.1172/jci.insight.124174.
5
The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome.（前）肾素受体：高血压和代谢综合征的一个新兴参与者。
Kidney Int. 2019 May;95(5):1041-1052. doi: 10.1016/j.kint.2018.10.042. Epub 2019 Feb 26.
6
Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin-angiotensin system.氯沙坦可预防脂肪组织-PRR 缺乏型雌性小鼠血压升高，而循环 sPRR 升高会激活肾素-血管紧张素系统。
Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H506-H515. doi: 10.1152/ajpheart.00473.2018. Epub 2018 Dec 14.
7
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Elevated plasma soluble (pro)renin receptor levels are associated with left ventricular remodeling and renal function in chronic heart failure patients with reduced ejection fraction.血浆可溶性（pro）肾素受体水平升高与射血分数降低的慢性心力衰竭患者的左心室重构和肾功能有关。
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Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies.成年小鼠 Atp6ap2 基因敲除导致多器官缺陷而致死。
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