可溶性（前）肾素受体缺失可减轻血管紧张素 II 诱导的高血压和肾脏损伤。
Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury.
机构信息
Division of Nephrology and Hypertension (N.R., D.S., C.S.P., C.H., W.W., D.E.K.), University of Utah Health, Salt Lake City.
Nutrition and Integrative Physiology (J.M.C., J.D.S.), University of Utah Health, Salt Lake City.
出版信息
Circ Res. 2021 Jun 25;129(1):50-62. doi: 10.1161/CIRCRESAHA.120.317532. Epub 2021 Apr 23.
Abstract
[Figure: see text].
摘要
[图：见正文]。
相似文献
1
Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury.可溶性（前）肾素受体缺失可减轻血管紧张素 II 诱导的高血压和肾脏损伤。
Circ Res. 2021 Jun 25;129(1):50-62. doi: 10.1161/CIRCRESAHA.120.317532. Epub 2021 Apr 23.
2
ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury.埃拉贝拉通过拮抗肾内肾素-血管紧张素系统来降低血压并防止肾脏损伤。
Am J Physiol Renal Physiol. 2020 May 1;318(5):F1122-F1135. doi: 10.1152/ajprenal.00606.2019. Epub 2020 Mar 16.
3
(Pro)renin receptor knockdown in the paraventricular nucleus of the hypothalamus attenuates hypertension development and AT receptor-mediated calcium events.下丘脑室旁核中（前体）肾素受体的敲低可减轻高血压的发展以及血管紧张素受体介导的钙事件。
Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1389-H1405. doi: 10.1152/ajpheart.00780.2018. Epub 2019 Mar 29.
4
Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice.集合管肾素原受体基因敲除可降低血管紧张素II诱导的高血压小鼠的肾功能，增加钠排泄，并减轻肾脏反应。
Am J Physiol Renal Physiol. 2017 Dec 1;313(6):F1243-F1253. doi: 10.1152/ajprenal.00152.2017. Epub 2017 Aug 16.
5
Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein.血管紧张素II通过激活环磷酸腺苷反应元件结合蛋白来调节脑（前）肾素受体的表达。
Am J Physiol Regul Integr Comp Physiol. 2015 Jul 15;309(2):R138-47. doi: 10.1152/ajpregu.00319.2014. Epub 2015 May 20.
6
The macula densa prorenin receptor is essential in renin release and blood pressure control.致密斑的原肾素受体对于肾素释放和血压控制至关重要。
Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F521-F534. doi: 10.1152/ajprenal.00029.2018. Epub 2018 Apr 18.
7
Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system.神经元人（前）肾素受体的过表达介导中枢神经系统中血管紧张素 II 非依赖性血压调节。
Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H580-H592. doi: 10.1152/ajpheart.00310.2017. Epub 2017 Dec 15.
8
Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice.（pro）肾素受体表达增加不会导致小鼠高血压或心脏和肾脏纤维化。
Lab Invest. 2014 Aug;94(8):863-72. doi: 10.1038/labinvest.2014.83. Epub 2014 Jul 21.
9
Role of (pro)renin receptor in albumin overload-induced nephropathy in rats.（原）肾素受体在白蛋白过载诱导大鼠肾病中的作用。
Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1759-F1768. doi: 10.1152/ajprenal.00071.2018. Epub 2018 May 30.
10
Cardiovascular and renal pathologic implications of prorenin, renin, and the (pro)renin receptor: promising young players from the old renin-angiotensin-aldosterone system.原肾素、肾素和（前）肾素受体的心血管和肾脏病理意义：来自旧肾素-血管紧张素-醛固酮系统的有前途的年轻选手。
J Cardiovasc Pharmacol. 2010 Nov;56(5):570-9. doi: 10.1097/fjc.0b013e3181f21576.
引用本文的文献
1
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy.动脉僵硬度与血管衰老：机制、预防及治疗
Signal Transduct Target Ther. 2025 Sep 1;10(1):282. doi: 10.1038/s41392-025-02346-0.
2
Annexin-A1 deficiency uncovers female-specific pathways in blood pressure control and cardiovascular remodeling in mice.膜联蛋白-A1缺乏揭示了小鼠血压控制和心血管重塑中女性特异性途径。
Commun Biol. 2025 Jul 6;8(1):955. doi: 10.1038/s42003-025-08291-6.
3
Epigenetics of Hypertensive Nephropathy.高血压肾病的表观遗传学
Biomedicines. 2024 Nov 16;12(11):2622. doi: 10.3390/biomedicines12112622.
4
Sex differences in the adrenal circadian clock: a role for BMAL1 in the regulation of urinary aldosterone excretion and renal electrolyte balance in mice.肾上腺昼夜节律钟的性别差异：BMAL1在调节小鼠尿醛固酮排泄和肾脏电解质平衡中的作用。
Am J Physiol Renal Physiol. 2025 Jan 1;328(1):F1-F14. doi: 10.1152/ajprenal.00177.2024. Epub 2024 Oct 24.
5
Collecting Duct Pro(Renin) Receptor Contributes to Unilateral Ureteral Obstruction-Induced Kidney Injury via Activation of the Intrarenal RAS.收集管 Pro（血管紧张素原）受体通过激活肾内 RAS 促进单侧输尿管梗阻诱导的肾脏损伤。
Hypertension. 2024 Oct;81(10):2152-2161. doi: 10.1161/HYPERTENSIONAHA.123.21740. Epub 2024 Aug 22.
6
Importance of the (Pro)renin Receptor in Activating the Renin-Angiotensin System During Normotensive and Preeclamptic Pregnancies.（前）肾素受体在正常妊娠和子痫前期激活肾素-血管紧张素系统中的重要性。
Curr Hypertens Rep. 2024 Dec;26(12):483-495. doi: 10.1007/s11906-024-01316-1. Epub 2024 Aug 2.
7
Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2.以高密度脂蛋白蛋白质组为靶点治疗新冠病毒急性后遗症
Int J Mol Sci. 2024 Apr 20;25(8):4522. doi: 10.3390/ijms25084522.
8
Assessment of the (Pro)renin Receptor Protein Expression in Organs.器官中（前）肾素受体蛋白表达的评估。
Curr Issues Mol Biol. 2024 Feb 25;46(3):1741-1753. doi: 10.3390/cimb46030113.
9
Functional Roles of Furin in Cardio-Cerebrovascular Diseases.弗林蛋白酶在心血管疾病中的功能作用
ACS Pharmacol Transl Sci. 2024 Feb 7;7(3):570-585. doi: 10.1021/acsptsci.3c00325. eCollection 2024 Mar 8.
10
Human soluble prorenin receptor expressed in mouse renal collecting duct shows sex-specific effect on cardiorenal function.在小鼠肾集合管中表达的人可溶性原肾素受体对心肾功能具有性别特异性影响。
Am J Physiol Renal Physiol. 2024 Apr 1;326(4):F611-F621. doi: 10.1152/ajprenal.00375.2023. Epub 2024 Feb 22.
本文引用的文献
1
Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells.可溶性（前）肾素受体调节 ENaC 参与培养的集合管细胞中的醛固酮信号传导。
Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F817-F825. doi: 10.1152/ajprenal.00436.2019. Epub 2019 Dec 16.
2
Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice.可溶性肾素前体受体可增加高脂喂养雄性小鼠的血压。
Hypertension. 2019 Oct;74(4):1014-1020. doi: 10.1161/HYPERTENSIONAHA.119.12906. Epub 2019 Aug 5.
3
The (pro)renin receptor in health and disease.在健康和疾病中的（前）肾素受体。
Nat Rev Nephrol. 2019 Nov;15(11):693-712. doi: 10.1038/s41581-019-0160-5.
4
Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability.站点 1 蛋白酶衍生的可溶性（前）肾素受体靶向血管加压素受体 2 以增强尿液浓缩能力。
JCI Insight. 2019 Apr 4;4(7). doi: 10.1172/jci.insight.124174.
5
The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome.（前）肾素受体：高血压和代谢综合征的一个新兴参与者。
Kidney Int. 2019 May;95(5):1041-1052. doi: 10.1016/j.kint.2018.10.042. Epub 2019 Feb 26.
6
Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin-angiotensin system.氯沙坦可预防脂肪组织-PRR 缺乏型雌性小鼠血压升高，而循环 sPRR 升高会激活肾素-血管紧张素系统。
Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H506-H515. doi: 10.1152/ajpheart.00473.2018. Epub 2018 Dec 14.
7
Circulating metabolites of strawberry mediate reductions in vascular inflammation and endothelial dysfunction in db/db mice.草莓循环代谢物可减轻 db/db 小鼠的血管炎症和内皮功能障碍。
Int J Cardiol. 2018 Jul 15;263:111-117. doi: 10.1016/j.ijcard.2018.04.040. Epub 2018 Apr 12.
8
Elevated plasma soluble (pro)renin receptor levels are associated with left ventricular remodeling and renal function in chronic heart failure patients with reduced ejection fraction.血浆可溶性（pro）肾素受体水平升高与射血分数降低的慢性心力衰竭患者的左心室重构和肾功能有关。
Peptides. 2019 Jan;111:152-157. doi: 10.1016/j.peptides.2018.04.010. Epub 2018 Apr 13.
9
(Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells.(Pro) 肾素受体介导白蛋白诱导的细胞反应：位点 1 蛋白酶衍生的可溶性 (pro) 肾素受体在肾上皮细胞中的作用。
Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C632-C643. doi: 10.1152/ajpcell.00006.2017. Epub 2017 Sep 13.
10
Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies.成年小鼠 Atp6ap2 基因敲除导致多器官缺陷而致死。
Sci Rep. 2017 Aug 29;7(1):9618. doi: 10.1038/s41598-017-08845-7.
Zotero 插件