Anniko M, Schmidt S H
Department of Oto-Rhino-Laryngology-Head and Neck Surgery, Umeå University Hospital, Sweden.
Acta Otolaryngol. 1988 Mar-Apr;105(3-4):255-65. doi: 10.3109/00016488809097006.
Instillation of EMLA, a new local anesthetic, into the middle ear of the guinea pig caused severe morphological damage to the organ of Corti in the first 4 mm from the round window. Further up the cochlea, only derangements of the stereocilia were found. The extent of morphological damage was the same, whether the agent was administered once or several times. The ototoxic potential of EMLA was obvious and is probably due to direct damage in areas where present in high concentrations. Over a short distance of approximately 0.1 mm there is a transition from a total destruction of the organ of Corti to a completely normal morphology.
将一种新型局部麻醉剂恩纳（EMLA）滴入豚鼠中耳，导致圆窗起4毫米范围内的柯蒂氏器出现严重形态损伤。在耳蜗更靠上的部位，仅发现静纤毛排列紊乱。无论该药剂是单次给药还是多次给药，形态损伤的程度都是相同的。恩纳的耳毒性潜力明显，可能是由于其在高浓度存在区域造成的直接损伤。在大约0.1毫米的短距离内，柯蒂氏器从完全破坏过渡到完全正常的形态。
