Hjorth N, Harring M, Hahn A
Department of Dermatology, KAS Gentofte, Copenhagen, Denmark.
J Am Acad Dermatol. 1991 Nov;25(5 Pt 1):809-11. doi: 10.1016/s0190-9622(08)80974-7.
Twenty-one patients were included in a double-blind, placebo-controlled, cross-over study with a eutectic mixture of lidocaine and prilocaine (EMLA). EMLA or placebo was placed on the upper lip for 1 hour; diathermy was then performed for 10 minutes. The pain caused by diathermy was evaluated by the patients and the cosmetologist on a four-point scale. The results of the investigation showed that there was significantly less pain after application of 5 gm of EMLA cream on the upper lip than after application of placebo, assessed both by the patient and by the cosmetologist. Eighteen of 20 patients preferred EMLA (p less than 0.0001). Local reactions were few and mild.
21名患者被纳入一项双盲、安慰剂对照、交叉研究,使用利多卡因和丙胺卡因的共晶混合物(EMLA)。将EMLA或安慰剂敷在上唇1小时;然后进行10分钟的透热疗法。患者和美容师用四点量表评估透热疗法引起的疼痛。调查结果显示,在上唇涂抹5克EMLA乳膏后,患者和美容师评估的疼痛明显低于涂抹安慰剂后。20名患者中有18名更喜欢EMLA(p小于0.0001)。局部反应少且轻微。