Manowska J, Mazur L
Department of Animal Physiology, Jagiellonian University, Krakow, Poland.
Acta Physiol Hung. 1988;71(1):51-4.
Swiss mice were treated intraperitoneally with AET, 5-HT, MEA, or GSH, in a dose of 80 mg/kg of body weight, on the first day of gestation. On the 19th day of pregnancy, the fresh weight of liver of the foetuses, as well as glycogen content in 1 g of fresh tissue and in the whole organ were analysed. The determination of glycogen content in the foetal liver were made according to the anthrone method. As compared with controls, in the remaining groups of mice a lower fresh weight of foetal liver less glycogen per g of fresh tissue and a smaller total amount of glycogen in the whole organ were found. Among the compounds, AET appeared to be more toxic than 5-HT, MEA, and GSH.
在妊娠第一天，给瑞士小鼠腹腔注射80毫克/千克体重的AET、5-羟色胺、MEA或谷胱甘肽。在怀孕第19天，分析胎儿肝脏的鲜重以及每克新鲜组织和整个器官中的糖原含量。胎儿肝脏糖原含量的测定采用蒽酮法。与对照组相比，在其余几组小鼠中，发现胎儿肝脏的鲜重较低，每克新鲜组织中的糖原较少，整个器官中的糖原总量也较少。在这些化合物中，AET似乎比5-羟色胺、MEA和谷胱甘肽毒性更大。
