Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Phytother Res. 2021 Jul;35(7):3665-3672. doi: 10.1002/ptr.7060. Epub 2021 Apr 23.
Ventilator-associated pneumonia (VAP) resulting from bacterial infection is a prevalent medical problem in intensive care units (ICUs). The purpose of this study was to systematically review available studies on oral products employed to control and reduce VAP in patients undergoing tracheal intubation. This study was based on a systematic review of clinical trial data from science databases such as PubMed, Cochrane, Scopus, and Web of science. Articles were reviewed and selected according to defined criteria and assessed by the primary evaluation checklist. After a critical review of 3,143 search hits, only 18 relevant articles were finally selected for discussion. Our assessment revealed that chlorhexidine and some other oral herbal medications are beneficial in preventing VAP. Chlorhexidine oral dosage forms provide a remarkable role in oral health and prevention of VAP by decreasing the microbial flora in the mouth. Because of similar benefits and comparable effects, some herbal medicines can be suggested as a practical alternative to chlorhexidine.
呼吸机相关性肺炎（VAP）是重症监护病房（ICU）中常见的细菌感染性医学问题。本研究旨在系统回顾经气管插管患者用于控制和减少 VAP 的口腔产品的现有研究。本研究基于对科学数据库（如 PubMed、Cochrane、Scopus 和 Web of Science）中临床试验数据的系统综述。文章根据定义的标准进行审查和选择，并由主要评估检查表进行评估。经过对 3143 个搜索结果的严格审查，最终仅选择了 18 篇相关文章进行讨论。我们的评估表明，洗必泰和一些其他口腔草药药物在预防 VAP 方面是有益的。洗必泰口腔剂型通过减少口腔中的微生物菌群，在口腔健康和预防 VAP 方面发挥显著作用。由于具有相似的益处和相当的效果，一些草药可以被推荐为洗必泰的实用替代药物。
