细菌突破障碍促进转移。
Bacteria break barrier to promote metastasis.
机构信息
Department of Medicine, University of Florida, Gainesville, FL, USA.
Department of Medicine, University of Florida, Gainesville, FL, USA; Department of Infectious Diseases and Inflammation, University of Florida, Gainesville, FL, USA.
出版信息
Cancer Cell. 2021 May 10;39(5):598-600. doi: 10.1016/j.ccell.2021.03.009. Epub 2021 Apr 22.
Abstract
The intestinal microbiota promote colorectal cancer, but their role in metastasis is poorly defined. In this issue of Cancer Cell, Bertocchi et al. report that intratumoral bacteria disrupt the gut vascular barrier, causing bacterial dissemination to the liver and the formation of a premetastatic niche, favoring recruitment of metastatic cells.
摘要
肠道微生物群促进结直肠癌，但它们在转移中的作用尚未明确。在本期《癌细胞》中，Bertocchi 等人报道称，肿瘤内细菌破坏了肠道血管屏障，导致细菌播散到肝脏并形成一个预先转移的生态位，有利于转移细胞的募集。
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