Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow 226002, India.
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Raebareli, Lucknow 226002, India.
Drug Discov Today. 2021 Aug;26(8):1972-1979. doi: 10.1016/j.drudis.2021.04.011. Epub 2021 Apr 20.
Neurodegenerative disorders can arise as a result of amyloid-β production and misfolding of its protein. The complex anatomy of the brain and the unresolved mechanics of the central nervous system hinder drug delivery; the brain is sheathed in a highly protective blood-brain barrier, a tightly packed layer of endothelial cells that restrict the entry of certain substances into the brain. Nanotechnology has achieved success in delivery to the brain, with preclinical assessments showing an acceptable concentration of active drugs in the therapeutic range, and nanoparticles can be fabricated to inhibit amyloid and enhance the delivery of the therapeutic molecule. This review focuses on the interactions of nanoparticles with amyloid-β aggregates and provides an assessment of their theranostic potential.
神经退行性疾病可能是由于淀粉样蛋白-β的产生和其蛋白的错误折叠引起的。大脑的复杂解剖结构和中枢神经系统尚未解决的力学问题阻碍了药物的输送；大脑被一层高度保护的血脑屏障所包裹，这是一层紧密排列的内皮细胞，限制了某些物质进入大脑。纳米技术在向大脑输送药物方面取得了成功，临床前评估显示治疗范围内有可接受浓度的活性药物，并且可以制造纳米颗粒来抑制淀粉样蛋白并增强治疗分子的输送。本综述重点介绍了纳米颗粒与淀粉样蛋白-β聚集物的相互作用，并评估了它们的治疗潜力。
