UMR7206 Eco-Anthropologie, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique, Université de Paris, Paris, France.
UMR7206 Eco-Anthropologie, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique, Université de Paris, Paris, France.
Trends Genet. 2021 Jul;37(7):631-638. doi: 10.1016/j.tig.2021.03.005. Epub 2021 Apr 21.
The adaptation of populations to local environments often relies on the selection of optimal values for polygenic traits. Here, we first summarize the results obtained from different quantitative genetics and population genetics models, about the genetic architecture of polygenic traits and their response to directional selection. We then highlight the contribution of systems biology to the understanding of the molecular bases of polygenic traits and the evolution of gene regulatory networks involved in these traits. Finally, we discuss the need for a unifying framework merging the fields of population genetics, quantitative genetics and systems biology to better understand the molecular bases of polygenic traits adaptation.
群体对当地环境的适应通常依赖于多基因性状最优值的选择。在这里，我们首先总结了不同数量遗传学和群体遗传学模型关于多基因性状的遗传结构及其对定向选择的反应所得到的结果。然后，我们强调了系统生物学对理解多基因性状的分子基础以及涉及这些性状的基因调控网络进化的贡献。最后，我们讨论了需要一个统一的框架，将群体遗传学、数量遗传学和系统生物学领域结合起来，以更好地理解多基因性状适应的分子基础。
