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非重症 COVID-19 后持续症状的患病率和特征:一项前瞻性队列研究。

Prevalence and characteristics of persistent symptoms after non-severe COVID-19: a prospective cohort study.

机构信息

Infectious Diseases and Intensive Care Unit, Pontchaillou University Hospital, Rue Henri Le Guilloux, 35033, Rennes, France.

Virology, Pontchaillou University Hospital, Rennes, France.

出版信息

Eur J Clin Microbiol Infect Dis. 2021 Nov;40(11):2421-2425. doi: 10.1007/s10096-021-04261-y. Epub 2021 Apr 23.

Abstract

We performed a prospective cohort study of 311 outpatients with non-severe COVID-19 (187 women, median age 39 years). Of the 214 (68.8%) who completed the 6-week follow-up questionnaire, 115 (53.7%) had recovered. Others mostly reported dyspnea (n = 86, 40.2%), weight loss (n = 83, 38.8%), sleep disorders (n = 68, 31.8%), and anxiety (n = 56, 26.2%). Of those who developed ageusia and anosmia, these symptoms were still present at week 6 in, respectively, 11/111 (9.9%) and 19/114 (16.7%). Chest CT scan and lung function tests found no explanation in the most disabled patients (n = 23). This study confirms the high prevalence of persistent symptoms after non-severe COVID-19.

摘要

我们对 311 名非重症 COVID-19 门诊患者(187 名女性,中位年龄 39 岁)进行了前瞻性队列研究。在完成 6 周随访问卷的 214 名患者中(68.8%),115 名(53.7%)已康复。其他人主要报告呼吸困难(n=86,40.2%)、体重减轻(n=83,38.8%)、睡眠障碍(n=68,31.8%)和焦虑(n=56,26.2%)。味觉和嗅觉丧失的患者中,这些症状在第 6 周仍存在于 111 名中的 11 名(9.9%)和 114 名中的 19 名(16.7%)。胸部 CT 扫描和肺功能检查在最残疾的患者(n=23)中未发现任何解释。本研究证实了非重症 COVID-19 后持续存在症状的高患病率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a7/8064701/66b9880cfaaf/10096_2021_4261_Fig1_HTML.jpg

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