University of Iowa, 1182 Biomedical Laboratories, 500 Newton Road, Iowa City, 52242, USA.
Curr Rheumatol Rep. 2021 Apr 24;23(5):32. doi: 10.1007/s11926-021-00994-z.
This review will cover foundational studies and recent findings that established key concepts for understanding the importance of redox biology to chondrocyte mitochondrial function and osteoarthritis pathophysiology after injury.
Articular chondrocyte mitochondria can be protected with a wide variety of antioxidants that will be discussed within a framework suggested by classic studies. These agents not only underscore the importance of thiol metabolism and associated redox function for chondrocyte mitochondria but also suggest complex interactions with signal transduction pathways and other molecular features of osteoarthritis that require more thorough investigation. Emerging evidence also indicates that reductive stress could occur alongside oxidative stress. Recent studies have shed new light on historic paradoxes in chondrocyte redox and mitochondrial physiology, leading to the development of promising disease-modifying therapies for posttraumatic osteoarthritis.
本篇综述将涵盖基础研究和近期发现，这些研究确立了氧化还原生物学对于理解软骨细胞线粒体功能和损伤后骨关节炎病理生理学重要性的关键概念。
关节软骨细胞的线粒体可以通过多种抗氧化剂进行保护，这将在经典研究提出的框架内进行讨论。这些药物不仅强调了硫醇代谢和相关氧化还原功能对于软骨细胞线粒体的重要性，还表明了与信号转导途径和骨关节炎的其他分子特征的复杂相互作用，这些都需要更深入的研究。新出现的证据还表明，还原性应激可能与氧化性应激同时发生。最近的研究揭示了软骨细胞氧化还原和线粒体生理学中的历史悖论，为创伤后骨关节炎的潜在治疗方法提供了新的希望。
