Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Department of Pediatrics & Neonatology and Division of Research, Aarupadai Veedu Medical College & Hospital, Vinayaka Mission's Research Foundation, Pondicherry, 607403, India.
Indian J Pediatr. 2021 Jul;88(7):696-702. doi: 10.1007/s12098-021-03748-y. Epub 2021 Apr 24.
Sepsis emerges as a complex clinical syndrome with activation of an innate host response to infections. Despite advancement in therapeutic approaches, infants with sepsis remain hospitalized for longer durations and it remains to be a major health problem in today's world. Zinc as a trace element, has the potential to improve the host's defence mechanism against various pathogenic diseases. During sepsis, a redistribution of zinc from serum into the liver has been observed and earlier studies imply a correlation between serum zinc levels and the outcome of sepsis. Zinc also appears to have a potential to be used as a biomarker of sepsis outcome. There are only few reports available to show the efficacy of zinc supplements in the management of neonatal sepsis.
败血症是一种复杂的临床综合征，其特征是先天宿主对感染的反应被激活。尽管治疗方法有所进步，但患有败血症的婴儿仍需住院更长时间，这仍然是当今世界的一个主要健康问题。锌作为一种微量元素，具有改善宿主防御机制以抵抗各种病原性疾病的潜力。在败血症期间，已经观察到锌从血清重新分配到肝脏，早期研究表明血清锌水平与败血症的结果之间存在相关性。锌似乎也有可能作为败血症结果的生物标志物。只有少数报道显示锌补充剂在新生儿败血症管理中的疗效。
