Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Department of General Dentistry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Biomed Pharmacother. 2021 Jul;139:111622. doi: 10.1016/j.biopha.2021.111622. Epub 2021 Apr 21.
Long non-coding RNAs (lncRNAs) are a group of transcripts that have been considered essential participants in cancer pathogenesis and progression over the past few decades. Small nucleolar RNA host gene 8 (SNHG8) is a newly discovered lncRNA that belongs to the SNHG family, a group of transcripts that can be processed into small nucleolar RNAs and exert important biological functions. As an oncogenic factor, SNHG8 is upregulated in multiple cancer types. Herein, we summarize the biological role of SNHG8 in different cancer types and the underlying mechanisms related to the interaction between SNHG8 and microRNAs, mRNAs, and proteins. In addition, this study emphasizes the clinical value of SNHG8 in cancer, hoping to provide new insights into cancer diagnosis, prognosis, and treatment.
长链非编码 RNA（lncRNAs）是过去几十年中被认为是癌症发病机制和进展中不可或缺的参与者的一组转录本。小核仁 RNA 宿主基因 8（SNHG8）是一种新发现的 lncRNA，属于 SNHG 家族，该家族的转录本可以被加工成小核仁 RNA，并发挥重要的生物学功能。作为一种致癌因子，SNHG8 在多种癌症类型中上调。本文总结了 SNHG8 在不同癌症类型中的生物学作用及其与 microRNAs、mRNAs 和蛋白质相互作用的潜在机制。此外，本研究强调了 SNHG8 在癌症中的临床价值，希望为癌症的诊断、预后和治疗提供新的思路。
