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综述文章:营养在酒精性肝病中的作用。

Review article: the role of nutrition in alcohol-associated liver disease.

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University, Indianapolis, IN, USA.

出版信息

Aliment Pharmacol Ther. 2021 Jun;53(12):1268-1276. doi: 10.1111/apt.16380. Epub 2021 Apr 25.

Abstract

BACKGROUND

Malnutrition is a commonly encountered issue in patients with alcohol-associated liver disease. The role of nutritional supplementation in the management of alcohol-associated liver disease is integral to patient outcomes-it has been shown to decrease rates of hepatic encephalopathy, improve outcomes post-liver transplant, reduce 90-day hospital readmissions and lower mortality. Despite these benefits, many studies have shown nutritional support to be an underutilised tool in the care of patients with alcohol-associated liver disease.

AIMS

To review the epidemiology, pathophysiology, recommendations for nutritional assessment and supplementation, as well as future directions for research of the relationship between nutrition and alcohol-associated liver disease.

METHODS

A literature search was conducted via PubMed using MeSH terms to inform this narrative review.

RESULTS

Decreased dietary intake, socioeconomic status, impaired absorption of nutrients and increased free radical species are implicated in the pathophysiology of malnutrition in alcohol-associated liver disease.

CONCLUSIONS

Malnutrition is common in alcohol-associated liver disease, and physicians should be aware of its association with poor clinical outcomes. Routine nutritional assessment, involvement of a dietician and nutritional supplementation are recommended to improve clinical outcomes in patients with alcohol-associated liver disease.

摘要

背景

营养不良是酒精性肝病患者常见的问题。营养补充在酒精性肝病管理中的作用对于患者的预后至关重要,它可以降低肝性脑病的发生率、改善肝移植后的结局、降低 90 天内的住院再入院率和降低死亡率。尽管有这些益处,但许多研究表明,营养支持在酒精性肝病患者的治疗中未得到充分利用。

目的

回顾营养与酒精性肝病关系的流行病学、病理生理学、营养评估和补充建议,以及研究的未来方向。

方法

通过 PubMed 使用 MeSH 术语进行文献检索,以进行此叙述性综述。

结果

膳食摄入减少、社会经济地位低下、营养物质吸收受损以及自由基增加都与酒精性肝病中的营养不良有关。

结论

酒精性肝病患者中营养不良很常见,医生应了解其与不良临床结局的关系。建议对酒精性肝病患者进行常规营养评估、营养师参与和营养补充,以改善临床结局。

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