Völcker H E, Naumann G O, Rentsch F, Wollensak J
Klin Monbl Augenheilkd. 1977 Oct;171(4):489-99.
Between 1964 and 1974 a primary reticulum-cellsarcoma of the retina was diagnosed histologically in 5 patients (between 44 and 71 years), in one already clinically. The initial diagnosis had been "uveitis" (2), "panuveitis" (1), "iridocyclitis with central retinal artery occlusion" (1), and "chorioretinitis" (1). The usual antiinflammatory therapy was without effect in every instance. All patients showed neurological symptoms with cerebral manifestations. Twice the cerebral biopsies had been misinterpreted initially as "atypical glioblastoma multiforme", once as Neuro-Behçet. The disease progressed over a course of 2--10 years from the initial ophthalmic symptoms to death. A review of the literature is given and the differential-diagnosis to necrotizing forms of retinitis, dissiminated chorioiditis neoplastic processes of retina and uvea and degenerative diseases are discussed. The primary reticulum-cellsarcoma of the retina must be considered in the differential-diagnosis of uveitis or panuveitis if 1. there is progression in spite of the usual antiinflammatory therapy, 2. the initial infiltrations are seen in the deep layers of the sensory retina.
1964年至1974年间，5例患者（年龄在44至71岁之间）经组织学诊断为原发性视网膜网状细胞肉瘤，其中1例已出现临床症状。最初的诊断分别为“葡萄膜炎”（2例）、“全葡萄膜炎”（1例）、“虹膜睫状体炎伴视网膜中央动脉阻塞”（1例）和“脉络膜视网膜炎”（1例）。所有病例采用的常规抗炎治疗均无效。所有患者均出现神经系统症状及脑部表现。两次脑活检最初均被误诊为“非典型多形性胶质母细胞瘤”，一次被误诊为神经白塞病。疾病从最初的眼部症状开始，历经2至10年发展至死亡。文中对相关文献进行了综述，并讨论了与坏死性视网膜病变、播散性脉络膜炎、视网膜和葡萄膜的肿瘤性病变以及退行性疾病的鉴别诊断。在葡萄膜炎或全葡萄膜炎的鉴别诊断中，若出现以下情况则必须考虑原发性视网膜网状细胞肉瘤：1. 尽管采用了常规抗炎治疗仍有病情进展；2. 最初的浸润出现在感觉视网膜深层。
