Department of Gynecology, Harbin Medical University Tumor Hospital, Harbin 150001, China.
The Seventh Department of Internal Medicine, Harbin Medical University Tumor Hospital, Harbin 150001, China.
Aging (Albany NY). 2021 Apr 25;13(8):12058-12066. doi: 10.18632/aging.202911.
The critical importance of circular RNAs (circRNAs) in human cancers, including ovarian cancer, has been discovered in the recent years. However, the roles of circ_0007841 in ovarian cancer remain unknown. In the current study, it was found that circ_0007841 expression was upregulated in ovarian cancer tissues and cell lines. Upregulation of circ_0007841 in patients with ovarian cancer predicts poor prognosis. Loss-of-function experiments discovered that circ_0007841 knockdown suppressed the proliferation, migration and invasion of ovarian cancer cells and . In terms of mechanism, circ_0007841 worked as a competing endogenous RNA (ceRNA) for miR-151-3p to facilitate MEX3C expression. Restoration of MEX3C level recovered the proliferation, migration and invasion of ovarian cancer cells. In conclusion, this study demonstrated that circ_0007841/miR-151-3p/MEX3C axis exerted important oncogenic functions in ovarian cancer.
近年来，人们发现环状 RNA（circRNAs）在包括卵巢癌在内的人类癌症中具有至关重要的作用。然而，circ_0007841 在卵巢癌中的作用仍不清楚。在本研究中，研究人员发现 circ_0007841 在卵巢癌组织和细胞系中表达上调。卵巢癌患者 circ_0007841 表达上调预示着预后不良。功能丧失实验发现，circ_0007841 敲低抑制了卵巢癌细胞的增殖、迁移和侵袭。从机制上讲，circ_0007841 作为 miR-151-3p 的竞争性内源 RNA（ceRNA）促进 MEX3C 的表达。恢复 MEX3C 水平恢复了卵巢癌细胞的增殖、迁移和侵袭。总之，本研究表明 circ_0007841/miR-151-3p/MEX3C 轴在卵巢癌中发挥了重要的致癌作用。
