J Biomed Nanotechnol. 2020 Jun 1;16(6):876-884. doi: 10.1166/jbn.2020.2941.
Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Cases of colon cancer have experienced dramatic growth for the past few decades in China, while the rate of rectal cancer descends 3% every year in the West. The purpose of this study is to reveal the potential impact of miR-21-5p on the occurrence process of CRC and its connection with a close homolog of L1 (CHL1). In this study, the expression level of the miR-151-3p was found to be significantly higher in colon adenocarcinoma tissue compared with adjacent normal tissues, while the CHL1 was lower in colon adenocarcinoma tissues. The expression of miR-151-3p was inversely correlated with the expression of CHL-1, as it was confirmed with correlation analysis. miR-151-3p deregulates the expression of CHL1. CHL1 overexpression can restrain the proliferation and invasion of CRC. Tumorigenesis experiments showed that the tumor growth rate of CHL1-OV was significantly reduced in mice, and its effect could be reversed by miR-151-3p mimics. Taken together, our study may provide new insights into the potential mechanisms of progression of CRC, and may provide a theory for targeted drug therapy.
结直肠癌（CRC）是世界上最常见的恶性肿瘤之一。在过去几十年中，中国的结肠癌病例经历了急剧增长，而西方的直肠癌发病率每年下降 3%。本研究旨在揭示 miR-21-5p 对 CRC 发生过程的潜在影响及其与 L1 同源物（CHL1）的关系。在这项研究中，发现 miR-151-3p 在结肠腺癌组织中的表达水平明显高于相邻的正常组织，而 CHL1 在结肠腺癌组织中较低。通过相关性分析证实，miR-151-3p 的表达与 CHL-1 的表达呈负相关。miR-151-3p 调节 CHL1 的表达。CHL1 过表达可抑制 CRC 的增殖和侵袭。肿瘤发生实验表明，在小鼠中 CHL1-OV 的肿瘤生长速度明显降低，而 miR-151-3p 模拟物可逆转其作用。综上所述，我们的研究可能为 CRC 进展的潜在机制提供新的见解，并为靶向药物治疗提供理论依据。
