Correlation between neutrophil-to-lymphocyte ratio with Gleason score in patients with prostate cancer at Adam Malik Hospital Medan 2013 - 2015.

CONTEXT

A grading system was created by Donald F. Gleason for prostate cancer as prognostic indicators. The neutrophil-to-lymphocyte ratio (NLR) was found that it could be a prognostic factor in solid tumors.

AIMS

This study aims to assess whether there is a correlation between NLR with the results of the Gleason score of patients with prostate adenocarcinoma biopsy at Haji Adam Malik Hospital Medan.

SETTINGS AND DESIGN

A total of 121 patients underwent a prostate biopsy from early January 2013 to December 2015 at Adam Malik Hospital.

SUBJECTS AND METHODS

Of the 121 patients, thirty were not included in the study because of incomplete baseline data and a history of hematological abnormalities. Data from 91 patients were then taken, including age, hematologic data prebiopsy, prostate-specific antigen (PSA) on initial examination, prostate weight estimation, and Gleason scores from biopsy results.

STATISTICAL ANALYSIS USED

The data are processed with SPSS version 22.

RESULTS

A significant moderate strength correlation was found between NLR and Gleason Score ( = 0.572; = 0.001). However, no statistically significant correlation found between NLR and prostate weight estimation ( = 0.077; = 0.469) and NLR with PSA ( = 0.072; = 0.496).

CONCLUSIONS

A significant correlation between the neutrophil-to-lymphocyte ratio and the Gleason score was noted. Further studies are needed to confirm these findings.