Hu Chao, Chen Cao, Dong Xiao-Ping
State Key Laboratory for Infectious Disease Prevention and Control, NHC Key Laboratory of Medical Virology and Viral Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Front Aging Neurosci. 2021 Apr 8;13:664965. doi: 10.3389/fnagi.2021.664965. eCollection 2021.
COVID-19 pandemic has already produced great impacts on global health security and social-economy. Elderly, particularly those with underlying diseases, are suffering from higher fatality rate. Neurodegenerative diseases are a group of incurable neurological disorders of loss of neuron and/or myelin sheath, which affect hundreds of millions of elderly populations and usually need long-term care. Older population is one of the most vulnerable to COVID-19 pandemic. In this report, we reviewed the current status of COVID-19 on the patients with several neurodegenerative diseases, particularly Alzheimer's disease, Parkinson's disease, prion disease, and amyotrophic lateral sclerosis. Meanwhile, the potential mechanisms of SARS-CoV-2 infection in the pathogenesis of neurodegenerative diseases were also summarized.
新冠疫情已经对全球卫生安全和社会经济产生了巨大影响。老年人，尤其是那些患有基础疾病的老年人，死亡率更高。神经退行性疾病是一组无法治愈的神经系统疾病，其特征是神经元和/或髓鞘丢失，影响着数亿老年人群，通常需要长期护理。老年人群是最易受新冠疫情影响的群体之一。在本报告中，我们综述了新冠病毒在几种神经退行性疾病患者中的现状，特别是阿尔茨海默病、帕金森病、朊病毒病和肌萎缩侧索硬化症。同时，还总结了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染在神经退行性疾病发病机制中的潜在机制。
