Jmii Souleimen, Cappadocia Laurent
Department of Chemistry, Université du Québec à Montréal, Montréal, QC, Canada.
Front Plant Sci. 2021 Apr 9;12:652170. doi: 10.3389/fpls.2021.652170. eCollection 2021.
Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses. Mechanistically, SUMOylation is a sequential multi-enzymatic process where SUMO E3 ligases accelerate SUMO conjugation while also influencing target identity and interactions. This review explores the biological functions of plant SUMO E3 ligases [SAP AND MIZ1 DOMAIN-CONTAINING LIGASE (SIZs), METHYL METHANESULFONATE-SENSITIVITY PROTEIN 21 (MMS21s), and PROTEIN INHIBITOR OF ACTIVATED STAT-LIKE (PIALs)] in relation to their molecular activities and domains. We also explore the sub-cellular localization of SUMO E3 ligases and review evidence suggesting a connection between certain SUMO E3 ligases and DNA that contributes to gene expression regulation.
小泛素样修饰物（SUMO）介导的蛋白质修饰在植物的多个过程中发挥重要作用，包括生长、发育以及对非生物胁迫的响应。从机制上讲，SUMO化是一个连续的多酶过程，其中SUMO E3连接酶加速SUMO缀合，同时还影响靶标的身份和相互作用。本综述探讨了植物SUMO E3连接酶[含SAP和MIZ1结构域的连接酶（SIZs）、甲磺酸甲酯敏感性蛋白21（MMS21s）和激活STAT样蛋白抑制剂（PIALs）]与其分子活性和结构域相关的生物学功能。我们还探讨了SUMO E3连接酶的亚细胞定位，并综述了表明某些SUMO E3连接酶与DNA之间存在联系从而有助于基因表达调控的证据。
