Saenz Daniel, Papanikolaou Niko, Zoros Emmanouil, Pappas Evangelos, Reiner Michael, Chew Lip Teck, Lim Hooi Yin, Hancock Sam, Nebelsky Alex, Njeh Christopher, Anagnostopoulos Georgios
University of Texas Health Science Center, San Antonio, TX, USA.
National and Kapodistrian University of Athens Medical School, Athens, Greece.
J Radiosurg SBRT. 2021;7(3):223-232.
The accuracy of stereotactic radiosurgery (SRS) to multiple metastases with a single-isocenter using high definition dynamic radiosurgery (HDRS) was evaluated across institutions. An SRS plan was delivered at six HDRS-capable institutions to an anthropomorphic phantom consisting of point, film, and 3D-gel dosimeters. Direct dose comparison and gamma analysis were used to evaluate the accuracy. Point measurements averaged across institutions were within 1.2±0.5%. The average gamma passing rate in the film was 96.6±2.2% (3%/2 mm). For targets within 4 cm of the isocenter, the 3D dosimetric gel gamma passing rate averaged across institutions was >90% (3%/2 mm). The targeting accuracy of high definition dynamic radiosurgery assessed by geometrical offset of the center of dose distributions across multiple institutions in this study was within 1 mm for targets within 4 cm of isocenter. Across variations in clinical practice, comparable dosimetry and localization is possible with this treatment planning and delivery technique.
跨机构评估了使用高清动态放射外科（HDRS）单等中心立体定向放射外科（SRS）治疗多发转移瘤的准确性。在六个具备HDRS能力的机构，将一个SRS计划施用于一个由点状、胶片和3D凝胶剂量仪组成的人体模型。采用直接剂量比较和伽马分析来评估准确性。各机构平均的点状测量结果在1.2±0.5%以内。胶片中的平均伽马通过率为96.6±2.2%（3%/2毫米）。对于距等中心4厘米以内的靶区，各机构平均的3D剂量学凝胶伽马通过率>90%（3%/2毫米）。在本研究中，通过多个机构剂量分布中心的几何偏移评估的高清动态放射外科的靶向准确性，对于距等中心4厘米以内的靶区在1毫米以内。在临床实践的各种变化中，使用这种治疗计划和施术技术可以实现可比的剂量测定和定位。
