Oyim James, Omolo Calvin A, Amuhaya Edith K
School of Pharmacy and Health Sciences, United States International University-Africa, Nairobi, Kenya.
Department of Chemistry, University of Nairobi, Nairobi, Kenya.
Front Chem. 2021 Apr 7;9:635344. doi: 10.3389/fchem.2021.635344. eCollection 2021.
The reduction of available drugs with effectiveness against microbes is worsening with the current global crisis of antimicrobial resistance. This calls for innovative strategies for combating antimicrobial resistance. Photodynamic Antimicrobial Chemotherapy (PACT) is a relatively new method that utilizes the combined action of light, oxygen, and a photosensitizer to bring about the destruction of microorganisms. This technique has been found to be effective against a wide spectrum of microorganisms, including bacteria, viruses, and fungi. Of greater interest is their ability to destroy resistant strains of microorganisms and in effect help in combating the emergence of antimicrobial resistance. This manuscript reviews porphyrins and porphyrin-type photosensitizers that have been studied in the recent past with a focus on their structure-activity relationship.
随着当前全球抗菌药物耐药性危机的加剧，有效对抗微生物的可用药物正在减少。这就需要创新的策略来对抗抗菌药物耐药性。光动力抗菌化疗（PACT）是一种相对较新的方法，它利用光、氧和光敏剂的联合作用来破坏微生物。已发现该技术对包括细菌、病毒和真菌在内的多种微生物有效。更令人感兴趣的是它们破坏耐药微生物菌株的能力，实际上有助于对抗抗菌药物耐药性的出现。本文综述了近期研究的卟啉和卟啉类光敏剂，重点关注它们的构效关系。
